蒙药巴特日-7治疗脓毒症胃肠功能障碍的研究进展  

Advances in managing sepsis-associated gastrointestinal dysfunction using Batri-7:insights from traditional Mongolianmedicine

作　　者：青格勒 乌云必力格 巴特金 包巴根那 郝浩[2] Qing Gele;Wu Yunbilige;Ba Tejin;Bao Bagenna;Hao Hao(Department of Emergency and Critical Care Medicine,International Mongolian Medicine Hospital,Inner Mongolia Autonomous Region,Hohhot,Oloo1o,Inner Mongolia Autonomous Region,China;Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Intensive Care Medicine Center,Jinan,250014,Shandong,China)

机构地区：[1]内蒙古自治区国际蒙医医院急诊与重症医学科,内蒙古自治区呼和浩特010010 [2]山东中医药大学附属医院重症医学科,山东济南250014

出　　处：《中国中西医结合急救杂志》2024年第5期634-637,共4页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

基　　金：内蒙古自治区公立医院高水平临床专科发展示范项目(2023SGGZ137);内蒙古自治区蒙医药学会科研项目(MXK-162)。

摘　　要：脓毒症是重症监护病房(ICU)中常见疾病之一,其发生机制是由宿主对感染的反应失调引起的多器官功能障碍。统计数据显示,约20.6%的ICU患者存在脓毒症。脓毒症容易导致胃肠功能障碍和急性肺、心、肾等器官损伤。脓毒症时肠道黏膜屏障作为正常肠道生理功能的重要组成部分,能有效阻止有害病原体进入器官及血液循环,从而降低脓毒症器官损伤的风险。但也因如此,肠道也成为了细菌和病毒最早攻击的器官,因此维护肠道黏膜屏障的完整性有助于改善脓毒症患者对肠内营养物质的吸收,并增强抵御微生物进入血液的能力,从而抑制脓毒症的发展。蒙药巴特日-7为内蒙古自治区蒙医医院常用方剂,因其有杀“黏”(细菌)的作用被应用于治疗肠炎、肺炎等炎症性疾病。该药作为本院急诊与重症医学科常规使用药物,常被用于治疗脓毒症胃肠功障碍、重症肺炎和其他肠道炎症性疾病方面。现通过探讨脓毒症的定义、发病机制、肠道屏障功能及蒙药巴特日-7在脓毒症患者肠道屏障功能障碍中的治疗与保护作用,为巴特日-7的临床应用提供理论支持。Sepsis is one of the common diseases in the intensive care unit(ICU),and its pathophysiological mechanism is characterized by a dysregulated host response to infection leading to multiple organ dysfunction.Statistical data indicate that approximately 20.6%of ICU patients have sepsis.Sepsis is prone to cause gastrointestinal dysfunction and acute damage to organs such as the lungs,heart,and kidneys.During sepsis,the intestinal mucosal barrier,as an essential component of normal intestinal physiological function,effectively prevents harmful pathogens from entering the organs and the bloodstream,thereby reducing the risk of organ damage associated with sepsis.However,due to this vulnerability,the intestine also hecomes one of the first organs attacked by bacteria and viruses.Therefore,maintaining the integrity of the intestinal mucosal barrier is crucial for improving the absorption of enteral nutrients in patients with severe sepsis and enhancing their ability against microbial entry into the bloodstream,thereby inhibiting the progression of sepsis,which carries significant clinical importance.The Mongolian medicine Bateri-7 is a commonly used formula in Mongolian hospitals in Inner Mongolia Autonomous Region,known for its antibacterial properties,and is applied in the treatment of inflammatory diseases such as enteritis and pneumonia.This medication is routinely used in our hospital's department of emergency and critical care medicine for treating gastrointestinal dysfunction in sepsis,severe pneumonia,and other intestinal inflammatory diseases.This paper will focus on discussing the definition of sepsis,its pathogenesis,the function of the intestinal barrier,and the therapeutic and protective effects of Mongolian medicine Bateri-7 in addressing intestinal barrier dysfunction in sepsis patients.providing theoretical support for the clinical application of Bateri-7.

关 键 词：脓毒症 肠黏膜屏障功能 蒙药巴特日-7 

分 类 号：R29[医药卫生—民族医学]