秦息痛对类风湿关节炎患者脑血管反应性及认知功能影响  

Effects of Qinxitong Tablet on Cerebrovascular Reactivity and Cognitive Function in Patients with Rheumatoid Arthritis

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作  者:李娟 闫俊 叶楠 高亚亚 陈庆平 刘丹 LI Juan;YAN Jun;YE Nan;GAO Yaya;CHEN Qingping;LIU Dan(Rheumatology and Immunology Department,Xi’an Fifth Hospital,Xi’an 710082,China;Neurology Department,Xi’an Fifth Hospital,Xi’an 710082,China)

机构地区:[1]西安市第五医院风湿免疫科,西安710082 [2]西安市第五医院神经内科,西安710082

出  处:《西安文理学院学报(自然科学版)》2024年第3期65-69,共5页Journal of Xi’an University(Natural Science Edition)

基  金:陕西省2021年科技计划项目(2021JZ-59);陕西省重点研发计划项目(2021SF-259);西安市创新能力强基计划项目(21YXYJ0003);西安市第五医院院内课题(2023dx01;2023lc07)

摘  要:研究中药秦息痛片联合甲氨蝶呤对类风湿关节炎患者脑血管反应性及认知功能的影响.选取2019年3月—2021年3月就诊于西安市第五医院306例类风湿关节炎活动期患者,并随机分为观察组和对照组,观察组给予口服秦息痛片联合甲氨蝶呤片,对照组单独给予甲氨蝶呤片.两组在治疗前及持续服用药物12个月后均通过TCD计算两组BHI以评估两组CVR变化,同时采用神经功能量表MoCA评分评估两组认知功能变化情况.治疗12个月后观察组BHI明显高于对照组,两组具有统计学差异(P<0.05);治疗12个月后观察组MoCA评分明显高于对照组,两组具有统计学差异(P<0.05);治疗12个月后观察组随着BHI的提高MoCA评分也逐渐增高,两者呈正相关关系(P<0.05).研究结果支持秦息痛片联合甲氨蝶呤可提高RA患者脑血管反应性并减缓患者认知功能损害,可能机理是通过秦息痛片对脑血管反应性的提高从而改善认知功能.To study the effects of Qinxitong tablet combined with Methotrexate on cerebrovascular reactivity and cognitive function in patients with Rheumatoid arthritis.306 patients with active Rheumatoid arthritis(RA)in Xi’an fifth hospital from March 2019 to March 2021 were randomly divided into observation group and control group.The observation group was given oral Qinxitong tablets combined with Methotrexate tablets,and the control group was given Methotrexate tablets alone.The breath holding index(BHI)of the two groups was calculated by transcranial Doppler ultra sound(TCD)to evaluate the changes of cerebrovascular reactivity(CVR).At the same time,MOCA score of neurological function scale was used to evaluate the changes of cognitive function in the two groups.The results showed:(1)There was significant difference in BHI between the two groups after 12 months of treatment(P<0.05);(2)After 12 months of treatment,the MOCA score of the observation group was higher than that of the control group,and there was significant difference between the two groups(P<0.05);(3)After 12 months of treatment,the MOCA score of the observation group gradually increased with the increase of BHI,and the two were positively correlated.Qinxitong tablets combined with Methotrexate can improve cerebrovascular reactivity and ease cognitive impairment.It may be through the protection of Qinxitong tablet on cerebrovascular reactivity to improve cognitive function.

关 键 词:类风湿关节炎 秦息痛 甲氨蝶呤 脑血管反应性 认知功能 

分 类 号:R54[医药卫生—心血管疾病]

 

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