血型ABO系统与脑型疟疾之间的相关性研究  

Association between ABO blood group system and cerebral malaria

作　　者：曹志龙 韩旭东[1] 张素燕[1] 林金锋[1] 王亚东[1] 胡玉明[2] CAO Zhilong;HAN Xudong;ZHANG Suyan;LIN Jinfeng;WANG Yadong;HU Yuming(Department of Critical Care Medicine,Nantong Third People's Hospital,Jiangsu 226006;Department of Rehabilitation Medicine,Affiliated Hospital of Nantong University)

机构地区：[1]南通市第三人民医院重症医学科,江苏226006 [2]南通大学附属医院康复医学科

出　　处：《南通大学学报(医学版)》2024年第6期536-539,共3页Journal of Nantong University(Medical sciences)

基　　金：南通市卫生健康委科研基金项目(MS2023076);南通市自然科学基金-面上项目(JCZ2023024)。

摘　　要：目的:探讨血型ABO系统与脑型疟疾的相关性。方法:选取2008年7月—2023年2月入住南通市第三人民医院重症医学科的57例恶性疟疾患者作为研究对象,其中脑型疟疾21例。收集患者的血型、血常规、降钙素原水平以及序贯器官衰竭评估(sequential organ failure assessment,SOFA)评分等指标,运用单因素分析与多因素Logistic回归分析方法,识别脑型疟疾发生的独立危险因素。结果:脑型疟疾患者与恶性非脑型疟疾患者在性别、年龄、最高体温、降钙素原水平、SOFA评分、血红蛋白水平等方面差异均无统计学意义(均P>0.05)。在脑型疟疾患者中,B型血占比最高(66.7%)(χ^(2)=9.26,P=0.002)。多因素Logistic回归分析结果显示,血型是脑型疟疾的影响因素(P=0.01,B=2.49,Exp(B)=12.00);而年龄、血红蛋白、降钙素原、PLT、最高体温等与脑型疟疾的发生无显著相关性(P>0.05)。结论:B型血个体可能面临更高的脑型疟疾风险,对于该群体的预防与治疗具有初步指导意义。Objective:To investigate the association between the ABO blood group system and cerebral malaria.Methods:A total of 57 patients diagnosed with severe malaria admitted to the Department of Infectious Diseases,Nantong Third People's Hospital,from July 2008 to February 2023 were included in this study,of whom 21 had cerebral malaria.Data on blood group,complete blood count,procalcitonin levels,and sequential organ failure assessment(SOFA)scores were comprehensively collected.Univariate analysis and multivariate Logistic regression analysis were performed to identify independent risk factors for cerebral malaria.Results:There were no statistically significant differences between patients with cerebral malaria and those with severe non-cerebral malaria in terms of sex,age,maximum body temperature,procalcitonin levels,SOFA scores,or hemoglobin levels(all P>0.05).However,a comparison of blood groups revealed that blood group B was the most prevalent among cerebral malaria patients,accounting for 66.7%of cases(χ^(2)=9.26,P=0.002).Multivariate Logistic regression analysis demonstrated that blood group(P=0.01,B=2.49,Exp(B)=12.00)was an influencing factor for cerebral malaria,while age,hemoglobin,procalcitonin,platelet count,and maximum body temperature were not significantly associated with cerebral malaria(P>0.05).Conclusion:This study identifies a significant association between blood group B and cerebral malaria,suggesting that it may be a potential risk factor,which provides further evidence for prevention and treatment.

关 键 词：ABO血型 脑型疟疾 序贯器官衰竭评估评分 

分 类 号：R531.3[医药卫生—内科学]