早产儿应用抗生素对肠道菌群及近期结局影响的研究进展  

Progress on the effects of antibiotics on intestinal flora and recent outcomes in premature infants

作　　者：厉运成 李亮亮[1] Li Yuncheng;Li Liangliang(Department of Pediatrics,Affiliated Hospital of Qingdao University,Qingdao 266000,China)

机构地区：[1]青岛大学附属医院儿科,266000

出　　处：《国际儿科学杂志》2024年第12期834-838,共5页International Journal of Pediatrics

摘　　要：新生儿时期是肠道菌群稳态建立的关键时期,抗生素对早产儿肠道菌群具有重要的驱动作用。新生儿短期和长期抗生素暴露可能会对肠道微生物定植产生不同程度的影响,导致肠道菌群多样性下降和物种组成变化,直接或间接参与炎症反应和免疫调节等过程。抗生素治疗可能对早产儿造成多种不良影响。该文阐述了早产儿抗生素暴露对肠道菌群及新生儿结局的影响。The neonatal period is a key period for the establishment of intestinal flora homeostasis,and antibiotics play a significant role in shaping the intestinal flora of preterm infants.Both early and long-term antibiotic exposure in preterm infants may have different degrees of influence on intestinal microbial colonization,resulting in decreased microbial diversity and alterations in species composition.These changes may directly or indirectly influence processes such as inflammatory responses and immune regulation.Antibiotic treatment may cause various adverse effects on premature infants.This paper reviewes the impact of antibiotic exposure on the intestinal flora and neonatal outcomes in preterm infants.

关 键 词：早产儿 肠道菌群 抗生素 

分 类 号：R72[医药卫生—儿科]