新生儿牛奶蛋白过敏发病相关因素研究进展  

Progress on the pathogenic factors of cow's milk protein allergy in neonates

作　　者：崔子鑫 张新华[2] Cui Zixin;ZhangXinhua(Department of Pediatrics,Shanxi Medical University Taiyuan 030001,China;Department of Neonatology,Shanxi Children's Hospital,Taiyuan 030000,China;Department of Neonatology,Changzhi People's Hospital,Changzhi 046000,China)

机构地区：[1]山西医科大学儿科医学系,太原030001 [2]山西省儿童医院新生儿内科,太原030000 [3]长治市人民医院新生儿科,046000

出　　处：《国际儿科学杂志》2024年第12期839-843,共5页International Journal of Pediatrics

基　　金：国家临床重点专科建设项目(新生儿科)。

摘　　要：牛奶蛋白过敏(cow's milk protein allergy,CMPA)是由免疫球蛋白E(immunoglobulin E,IgE)、非IgE或二者混合介导产生的复杂免疫反应。新生儿作为一个特殊群体,其营养全部来源于母乳和(或)配方乳,易发生CMPA。研究表明遗传因素、环境因素、免疫因素、肠黏膜屏障、宫内致敏、饮食因素、分娩方式、孕周胎龄可能与新生儿CMPA的发生均存在一定关系。该文将综合以上方面,对新生儿CMPA的发病因素进行综述,为早期识别与干预提供临床依据。Cow's milk protein allergy(CMPA)is a complex immune reaction mediated by immunoglobulin E(IgE),non-IgE or a mixture of the two.Neonate,as a special group,whose nutrition comes from breast milk and/or formula milk,are prone to CMPA.Studies have shown that genetic factors,environmental factors,immune factors,intestinal mucosal barrier,intrauterine sensitization,diet factors,delivery mode,gestational age may have a certain relationship with the occurrence of neonatal CMPA.This article will make a review on the pathogenic factors of neonatal CMPA from the above aspects,so as to provide clinical basis for its early identification and intervention.

关 键 词：牛奶蛋白过敏 新生儿 免疫 

分 类 号：R72[医药卫生—儿科]