A型肉毒毒素防治病理性瘢痕的研究进展  

Research Progress on botulinum toxin type A in preventing and treating pathological scars

作　　者：王勇[1] 赵娅琳 林艳 段星祥 朱占永[1] WANG Yong;ZHAO Yalin;LIN Yan;DUAN Xingxiang;ZHU Zhanyong(Department of Plastic Surgery,Renmin Hospital,Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院整形外科,430060

出　　处：《临床外科杂志》2024年第12期1333-1336,共4页Journal of Clinical Surgery

摘　　要：病理性瘢痕主要包括增生性瘢痕和瘢痕疙瘩,一直是皮肤科和烧伤整形外科的难点。目前,虽然有很多治疗方式被应用于病理性瘢痕相关的基础和临床研究,但临床上病理性瘢痕的防治尚无确切方案。A型肉毒毒素(BoNT-A)是皮肤科及整形美容外科广泛应用的药物,早在2000年就发现可用于改善瘢痕外观。近年来,有大量基础及临床实验对其在瘢痕预防和治疗中的作用进行了研究。本文就BoNT-A对病理性瘢痕的研究进展进行了综述。Pathological scars,primarily including hypertrophic scars and keloids,have long been a challenge for dermatology and burn plastic surgery.Despite numerous treatment methods being applied to basic and clinical research on pathological scarring,there is still no definitive scheme for its prevention and treatment.Botulinum Toxin Type A(BoNT-A),widely used in dermatology and aesthetic surgery since 2000 for improving scar appearance.In recent years,there have been a large number of basic and clinical experiments investigating the role of BoNT-A in the prevention and treatment of scars.This article reviews the progress of BoNT-A research on pathological scars to provide new perspectives for their prevention and treatment.

关 键 词：A型肉毒毒素 病理性瘢痕 增生性瘢痕 瘢痕疙瘩 

分 类 号：R62[医药卫生—整形外科]