琥珀酸美托洛尔缓释片联合阿托伐他汀钙片治疗冠心病的效果  

Efficacy of Metoprolol Succinate Sustained-release Tablets Combined with Atorvastatin Calcium Tablets in the Treatment of Coronary Heart Disease

作　　者：余丽娴 Yu Lixian(Department of Pharmacy,First Affiliated Hospital of Guangdong Pharmaceutical University,Guangzhou 510000,Guangdong Province,China)

机构地区：[1]广东药科大学附属第一医院药学部,广东广州510000

出　　处：《中外医药研究》2025年第1期31-33,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:观察琥珀酸美托洛尔缓释片联合阿托伐他汀钙片治疗冠心病的效果。方法:选取2021年8月—2022年8月广东药科大学附属第一医院收治的冠心病患者60例为研究对象,采用随机数字表法分为联合组和对照组,各30例。联合组使用琥珀酸美托洛尔缓释片联合阿托伐他汀钙片治疗,对照组使用阿托伐他汀钙片治疗。对比两组血液流变学指标水平、心功能指标水平、心绞痛症状、治疗效果、不良反应发生率。结果:治疗后,两组全血还原黏度、高切还原黏度、低切还原黏度降低,联合组低于对照组(P<0.05);治疗后,两组左心室收缩末期内径、左心室舒张末期内径降低,左室射血分数升高,联合组优于对照组(P<0.05);治疗后,两组心绞痛每周发作次数减少,持续时间缩短,联合组优于对照组(P<0.05);联合组治疗总有效率高于对照组(P=0.022);两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:琥珀酸美托洛尔缓释片联合阿托伐他汀钙片治疗冠心病的临床效果显著,可改善心肌供血,增强心功能,减轻心绞痛症状且未增加不良反应发生率。Objective:To observe the effect of metoprolol succinate sustained-release tablets combined with atorvastatin calcium tablets in the treatment of coronary heart disease.Methods:Sixty patients with coronary heart disease admitted to the First Affiliated Hospital of Guangdong Pharmaceutical University from August 2021 to August 2022 were selected as the study objects,and were divided into combined group and control group by random number table method,with thirty cases in each group.The combined group was treated with metoprolol succinate sustained-release tablets combined with atorvastatin calcium tablets,and the control group was treated with atorvastatin calcium tablets.Hemorheology index,cardiac function index,angina pectoris symptom,therapeutic effect and incidence of adverse reactions were compared between the two groups.Results:After treatment,the whole blood reductive viscosity,high reductive viscosity and low reductive viscosity of two groups were decreased,and the combined group was lower than the control group(P<0.05).After treatment,left ventricular end-systolic diameter and left ventricular end-diastolic diameter decreased and left ventricular ejection fraction increased in both groups,and the combined group was better than the control group(P<0.05).After treatment,the weekly frequency and duration of angina pectoris in the two groups were reduced,and the combined group was better than the control group(P<0.05).The total effective rate of the combined group was higher than that of the control group(P=0.022).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Metoprolol succinate sustained-release tablets combined with atorvastatin calcium tablets have significant clinical effects in the treatment of coronary heart disease,which can improve myocardial blood supply,enhance cardiac function,alleviate symptoms of angina pectoris and do not increase the incidence of adverse reactions.

关 键 词：冠心病 琥珀酸美托洛尔缓释片 阿托伐他汀钙片 

分 类 号：R541.4[医药卫生—心血管疾病]