脓毒症致死机制:补体与凝血系统的过度激活  

Lethal mechanisms of sepsis:overactivation of the complement and coagulation systems

作　　者：钱松赞 黄跃跃[1] 周炜[1] 娄辰 潘景业[1,2,3] Qian Songzan;Huang Yueyue;Zhou Wei;Lou Chen;Pan Jingye(Department of Intensive Care Unit,The First Affiliated Hospital of Wenzhou Medical University;Zhejiang Key Laboratory of Critical Care Medicine;Zhejiang Engineering Research Center or Hospital Emergency and Process Digitization,Wenzhou,China)

机构地区：[1]温州医科大学附属第一医院重症医学科 [2]浙江省全省重症医学重点实验室 [3]医院应急与流程数字化浙江省工程研究中心

出　　处：《实用休克杂志(中英文)》2024年第4期198-200,206,共4页Journal of Practical Shock

摘　　要：脓毒症是由感染引起的全身性炎症反应,通常导致多器官功能障碍甚至死亡,补体和凝血系统的过度激活在脓毒症发展中起着关键作用,是脓毒症致死的主要机制之一。免疫性血栓的形成是脓毒症病理过程中的重要环节,当免疫系统与凝血系统发生紊乱时,微血栓的生成可能进一步引发弥散性血管内凝血。补体和凝血系统相互交织,激发过度炎症反应与组织损伤,最终促进血栓形成并导致器官功能衰竭。结合国内外研究成果,本文分析脓毒症中补体和凝血系统的过度激活,旨在为脓毒症的防治与临床实践提供有益参考。Sepsis is a systemic inflammatory response triggered by infection,often leading to multiple organ dysfunction and even death.The excessive activation of the complement and coagulation systems plays a critical role in the onset and progression of sepsis,making it one of the primary mechanisms of sepsis-related mortality.The formation of immune thrombosis is an important aspect of the pathological process of sepsis.When dysregulation occurs between the immune and coagulation systems,the formation of microthrombi can further trigger disseminated intravascular coagulation.The complement and coagulation systems interact,triggering excessive inflammatory responses and tissue damage,which ultimately promotes thrombosis formation and leads to organ failure.Based on both domestic and international research findings,this article analyzes the excessive activation of the complement and coagulation systems in sepsis,aiming to provide valuable insights for the prevention,treatment,and clinical practice of sepsis.

关 键 词：脓毒症 致死机制 补体系统 凝血系统 免疫性血栓 

分 类 号：R54[医药卫生—心血管疾病]