脉冲射频治疗后经硬膜外腔导管连续药物输注和反复注射医用三氧对带状疱疹后神经痛的治疗价值  

The Therapeutic Value of Continuous Drug Infusion through Epidural Catheter and Repeated Injection of Ozone after Pulsed Radiofrequency Therapy for Postherpetic Neuralgia

作　　者：高爽 曹国庆[1] 倪家骧[1] GAO Shuang;CAO Guoqing;NI Jiaxiang(Pain Department,Xuanwu Hospital,Capital Medical University,Beijing 100053,China;Pain Department,Beijing Luhe Hospital Affiliated to Capital Medical University,Beijing 101149,China)

机构地区：[1]首都医科大学宣武医院疼痛科,北京100053 [2]首都医科大学附属北京潞河医院介入疼痛科,北京101149

出　　处：《转化医学杂志》2024年第9期1532-1535,1549,共5页Translational Medicine Journal

基　　金：北京市2015年度临床医学发展专项–“扬帆”计划项目(ZYLX201507)。

摘　　要：目的观察脉冲射频治疗后经硬膜外腔导管连续药物输注和反复注射医用三氧治疗带状疱疹后神经痛的效果。方法回顾性随机选取2020年11月至2022年6月首都医科大学附属北京潞河医院79例带状疱疹后神经痛患者,其中采用脉冲射频治疗后经硬膜外腔导管连续药物输注和反复注射三氧疗法治疗者43例(治疗组),脉冲射频治疗后单次三氧治疗者36例(对照组)。比较2组患者术前、术后、术后1个月、术后3个月、术后6个月疼痛视觉模拟评分法(VAS)评分,比较2组患者术后6个月睡眠、饮食、痛觉超敏改善情况。结果术前及术后,2组疼痛VAS评分比较差异无统计学意义(P>0.05);术后1、3、6个月,治疗组疼痛VAS评分均低于对照组同期,比较差异有统计学意义(P<0.05)。术后6个月,治疗组睡眠、饮食、痛觉超敏改善率分别为69.8%、83.7%、58.1%,对照组分别为27.8%、41.7%、25.0%,治疗组改善率均高于对照组(P<0.05)。。结论脉冲射频治疗后经硬膜外腔导管连续药物输注和反复注射医用三氧治疗带状疱疹后神经痛对患者疼痛症状的改善效果显著,且远期效果更佳。Objective To observe the effect of continuous drug infusion and repeated injection of medical ozone through an epidural catheter in the treatment of postherpetic neuralgia after pulsed radiofrequency therapy.Methods From November 2020 to June 2022,a total of 79 patients with postherpetic neuralgia were retrospectively selected from Beijing Luhe Hospital,Capital Medical University.Among them,43 patients underwent continuous drug infusion and repeated ozone injection therapy after pulsed radiofrequency therapy(treatment group),while 36 patients underwent single ozone therapy after pulsed radiofrequency therapy(control group).VAS scores of pain were compared before treatment,immediately after treatment,and at 1,3,and 6 months post-treatment.Additionally,sleep,diet,and pain hypersensitivity improvement rates were compared between the two groups at 6 months post-treatment.Results There were no significant differences in VAS scores between the two groups before and immediately after treatment(P>0.05).At 1,3,and 6 months post-treatment,the VAS scores in the treatment group were significantly lower than those in the control group(P<0.05).At 6 months post-treatment,the improvement rates of sleep,diet,and pain hypersensitivity in the treatment group were 69.8%,83.7%,and 58.1%,respectively,while those in the control group were 27.8%,41.7%,and 25.0%,respectively.The differences were statistically significant(P<0.05).Conclusion Continuous drug infusion and repeated injection of medical ozone through epidural catheter after pulsed radiofrequency therapy can significantly improve the symptoms of postherpetic neuralgia,with superior long-term efficacy.

关 键 词：神经痛 带状疱疹后 三氧治疗 注射 硬膜外 导管 留置 

分 类 号：R752.120.5[医药卫生—皮肤病学与性病学]