CT定位下微创引流术对高血压脑出血患者血清网膜素1及人星形胶质源性蛋白水平的影响  

Effect of CT-located minimally invasive drainage surgery on serum Omentin-1 and S100B levels in patients with hypertensive intracerebral hemorrhage

作　　者：朱秀聪 马威[1] 郭春梅[1] Zhu Xiucong;Ma Wei;Guo Chunmei(The 5th Ward of Neurosurgery Department,The First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院神经外科五病房,哈尔滨150001

出　　处：《中国医学装备》2025年第1期36-40,共5页China Medical Equipment

基　　金：黑龙江省卫生健康委科研课题(2020-130)。

摘　　要：目的:探讨CT定位下微创引流术对高血压脑出血患者血清网膜素1(Omentin-1)及人星形胶质源性蛋白(S100B)水平的影响。方法:选取2021年1月至2024年3月在哈尔滨医科大学附属第一医院诊断的120例高血压脑出血患者,按照随机数表法将其分为研究组和对照组,每组60例,研究组采用CT定位下微创引流术治疗,对照组采用常规开颅手术治疗。比较两组患者的治疗效果,神经功能、脑水肿、血清Omentin-1及S100B水平之间的差异。结果:研究组60例患者中显效45例(占75.00%),有效11例(占18.33%),无效4例(占6.67%),治疗总有效率为93.33%;对照组60例患者中显效6例(占10.00%),有效42例(占70.00%),无效12例(占20.00%),治疗总有效率为80.00%,研究组治疗总有效率显著高于对照组,差异有统计学意义(χ^(2)=4.621,P<0.05)。研究组术后6个月格拉斯哥预后量表(GOS)评分1级0例(占0.00%),2级6例(占10.00%),3级10例(占16.67%),4级2例(占3.33%),5级42例(占70.00%);对照组GOS评分1级2例(占3.33%),2级15例(占25.00%),3级5例(占8.33%),4级6例(占10.00%),5级32例(占53.33%);两组比较差异有统计学意义(U=2.112,P<0.05)。术后两组患者的脑水肿情况均得到显著的改善,且研究组术后2周和1个月的脑水肿体积显著低于对照组,两组比较差异有统计学意义(t=41.675、29.750,P<0.05)。两组患者血清Omentin-1、S100B均得到显著降低,且研究组术后Omentin-1、S100B显著低于对照组,两组比较差异有统计学意义(t=22.675、10.157,P<0.05)。结论:CT定位下微创引流术对高血压脑出血患者通过精确的CT定位引导,微创引流术能够有效减少脑出血区域的压力,促进血肿清除,同时通过调控血清Omentin-1和S100B水平,减少脑水肿,缓解脑组织损伤,术后神经功能恢复显著,整体治疗效果较好。Objective:To investigate the effect of computed tomography(CT)-guided minimally invasive drainage surgery on serum Omentin-1 and human astroglial derived protein(S100B)levels in patients with hypertensive intracerebral hemorrhage.Methods:A total of 120 patients with hypertensive intracerebral hemorrhage who were diagnosed in The First Affiliated Hospital of Harbin Medical University from January 2021 to December 2023 were included as the research subjects.According to the principle of random grouping,these patients were randomly divided into a study group and a control group,with 60 cases in each group.The study group adopted CT-located minimally invasive drainage surgery to conduct treatment,and the control group adopted conventional craniotomy to conduct treatment.The differences of curative effect,neurological function,cerebral edema,serum Omentin-1 and S100B levels between the two groups were compared.Results:In 60 patients of study group,45 cases showed significant improvement(75.00%),and 11 cases showed effective improvement(18.33%),and 4 cases showed invalid(6.67%),with an overall effective rate of 93.33%.In 60 patients of control group,6 cases showed significant improvement(10.00%),and 42 cases showed effective improvement(70.00%),and 12 cases showed invalid(20.00%),with an overall effective rate of 80.00%.The overall effective rate of study group was significantly higher than that of control group,and the difference was statistically significant(χ^(2)=4.621,P<0.05).The results of Glasgow Outcome Scale(GOS)scores of study group showed that 0 case was grade 1(0.00%),and 6 cases were grade 2(10.00%),and 10 cases were grade 3(16.67%),and 2 cases were grade 4(3.33%),and 42 cases were grade 5(70.00%).At the 6th month after surgery,the GOS scores of control group indicated that 2 cases were grade 1(3.33%),and 15 cases were grade 2(25.00%),and 5 cases were grade 3(8.33%),and 6 cases were grade 4(10.00%),and 32 cases were grade 5(53.33%).There was a statistically significant difference in GOS scores between the

关 键 词：CT定位 微创引流术 高血压脑出血 网膜素1(Omentin-1) 人星形胶质源性蛋白(S100B) 

分 类 号：R816.1[医药卫生—放射医学]