中医药防治肿瘤化疗相关性血小板减少症临床疗效及安全性Meta分析  

Meta Analysis of Clinical Efficacy and Safety of Traditional Chinese Medicine in the Prevention and Treatment of Tumor Chemotherapy Induced Thrombocytopenia

作　　者：钟佳 李为[2] 刘华[2] 伍静 李杳瑶[2] Zhong Jia;Li Wei;Liu Hua;Wu Jing;Li Yaoyao(Changsha Traditional Chinese Medicine Hospital,Changsha 410002,China;First Hospital Affiliated to Hunan University of Chinese Medicine,Changsha 410007,China)

机构地区：[1]长沙市中医医院,湖南长沙410002 [2]湖南中医药大学第一附属医院,湖南长沙410007

出　　处：《亚太传统医药》2025年第2期146-153,共8页Asia-Pacific Traditional Medicine

基　　金：湖南省临床医学研究中心(基地)项目(2021SK4023);湖南省自然科学基金(2021JJ30523);湖南中医药大学校级科研项目(2019XIJJ43)。

摘　　要：目的:系统评价中医药防治肿瘤化疗相关性血小板减少症(CIT)的临床疗效及安全性。方法:检索中国知网(CNKI)、维普、万方、中国生物医学文献数据库(CBM)、PubMed、Embase、Cochrane Library数据库中中医药防治CIT的随机对照临床试验,通过Revman 5.3进行Meta分析。结果:共纳入27篇文献,共1793例患者;Meta分析结果表明,中西医结合[MD=21.12,95%CI(13.76,28.47),P<0.00001]、中医[MD=23.11,95%CI(14.85,31.38),P<0.00001]治疗CIT能提升化疗后患者的血小板(PLT)计数,提高治疗的显效率[OR=3.7,95%CI(2.51,5.47),P<0.00001]、[OR=2.24,95%CI(1.19,4.22),P=0.01];中西结合与单纯西医在改善患者卡式评分(KPS)方面疗效相当[MD=1.55,95%CI(-2.80,5.90),P=0.48];中医在改善患者KPS评分方面优于西医[MD=23.11,95%CI(14.85,31.38),P<0.00001]。结论:中医、中西医结合治疗CIT能提升化疗后PLT计数,提高CIT治疗的显效率,中医治疗能改善患者的KPS评分。Objective:To systematically evaluate the clinical efficacy and safety of traditional Chinese medicine in the prevention and treatment of chemotherapy induced thrombocytopenia(CIT).Methods:Randomized controlled clinical trials on the prevention and treatment of CIT using traditional Chinese medicine were retrieved from CNKI,VIP,WanFang,China Biomedical Literature Disc(CBM disc),PubMed,Embase,and Cochrane Library databases,and meta-analysis was conducted by Revman 5.3.Results:The results included a total of 27 articles and 1793 patients.The results showed that the combination of traditional Chinese and Western medicine[MD=21.12,95%CI(13.76,28.47),P<0.00001],traditional Chinese medicine[MD=23.11,95%CI(14.85,31.38),P<0.00001]treatment of CIT can increase the PLT count of patients after chemotherapy and improve the treatment efficiency[OR=3.7,95%CI(2.51,5.47),P<0.00001],[OR=2.24,95%CI(1.19,4.22),P=0.01],The combination of traditional Chinese and Western medicine has a similar therapeutic effect in improving patients'KPS scores[MD=1.55,95%CI(-2.80,5.90),P=0.48],while traditional Chinese medicine is superior to Western medicine in improving patients'KPS scores[MD=23.11,95%CI(14.85,31.38),P<0.00001].Conclusion:Both traditional Chinese medicine and the combination of traditional Chinese and Western medicine can increase the PLT count after chemotherapy and improve the efficacy of CIT treatment.Traditional Chinese medicine treatment can improve the KPS score of patients.

关 键 词：化疗相关性血小板减少症 骨髓抑制 中医药 META分析 

分 类 号：R242[医药卫生—中医临床基础]