植物甾醇防治骨质疏松症作用机制研究进展  

Research Progress on the Mechanism of Action of Plant Sterols in thePrevention and Treatment of Osteoporosis

作　　者：梁海峰 宋敏 文皓楠 陈明杏 张荣伟 Liang Haifeng;Song Min;Wen Haonan;Chen Mingxing;Zhang Rongwei(Clinical College of Traditional Chinese Medicine,Gansu University of TraditionalChinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学中医临床学院,甘肃兰州730000

出　　处：《亚太传统医药》2025年第2期252-256,共5页Asia-Pacific Traditional Medicine

基　　金：国家自然科学基金项目(81960877、81960878);甘肃省高等学校产业支撑计划项目(2022CYZC-52)。

摘　　要：骨质疏松症(OP)是由于骨代谢失衡,引起骨骼微结构变化,脆性骨折风险增加,且具有发病率、致残率、致死率高特点的一类疾病。近年来发现存在于植物中的天然化合物植物甾醇具有抗骨质疏松症、抗炎、抗氧化、调节肠道菌群等作用,被广泛应用于骨质疏松症的防治。综述植物甾醇抗炎、抗氧化、调节肠道菌群以及调控相关信号通路防治骨质疏松症的作用机制,以期为临床预防和治疗OP提供新的策略。Osteoporosis(OP)is due to bone metabolic imbalance,increased risk of fragility fracture,morbidity,disability,and mortality.In recent years,the natural compounds found in plants have anti-osteoporosis,anti-inflammatory,antioxidant,regulation of intestinal flora,and are widely used in the prevention and control of osteoporosis.On the anti-inflammatory,antioxidant,regulation of the intestinal flora,and the regulation of related signaling pathways to prevent osteoporosis,in order to provide new strategies for clinical prevention and treatment of OP.

关 键 词：骨质疏松症 植物甾醇 骨代谢 作用机制 

分 类 号：R259[医药卫生—中西医结合]