富血小板血浆治疗对烧伤后增生性瘢痕的疗效研究  

Study on the Therapeutic Effect of Platelet Rich Plasma on Hypertrophic Scars after Burns

作　　者：刘胜利[1,3] 蔡杰 杨贵珍 郑健生 陈待庆[1] 戴泽宇 LIU Shengli;CAI Jie;YANG Guizhen;ZHENG Jiansheng;CHEN Daiqing;DAI Zeyu(Department of Burns and Plastic Surgery,the 909th Hospital(Dongnan Hospital of Xiamen University),Zhangzhou,363000 Fujian,China;Medical Office,Health Service Department,the 909th Hospital(Dongnan Hospital of Xiamen University),Zhangzhou,363000 Fujian,China;The First Affiliated Hospital of Fujian Medical University,Fuzhou 350005,China)

机构地区：[1]第九〇九医院(厦门大学附属东南医院)烧伤整形科,福建漳州363000 [2]第九〇九医院(厦门大学附属东南医院)卫勤处医疗办,福建漳州363000 [3]福建医科大学附属第一医院,福州350005

出　　处：《转化医学杂志》2024年第7期985-988,共4页Translational Medicine Journal

基　　金：福建省自然科学基金(2024J011575);第九〇九医院自主科研项目-面上项目(22MS006);漳州市自然科学基金项目(ZZ2023J50)。

摘　　要：目的探索自体富血小板血浆(PRP)对烧伤后增生性瘢痕的治疗作用。方法选取2016年9月至2023年6月第九O九医院收治的80例烧伤后增生性瘢痕患者为研究对象,按照随机数表法将患者分为试验组42例和对照组38例。对照组进行常规Meek皮肤移植治疗,试验组进行PRP联合Meek皮肤移植治疗,2组3个月和6个月后随访,比较2组临床疗效,温哥华瘢痕评定量表(VSS)和疼痛VAS评分以及瘢痕血流灌注量。结果试验组治疗总有效率显著高于对照组,差异有统计学意义(P<0.05);治疗3个月时,试验组的厚度,柔软性和总评分显著低于对照组,差异有统计学意义(P<0.05);治疗6个月时,试验组VSS各项评分及总评分均显著低于对照组,差异有统计学意义(P<0.05);治疗3个月和6个月时,试验组VAS评分均低于对照组,差异有统计学意义(P<0.05);治疗3个月和6个月时,试验组瘢痕血流灌注量均显著低于对照组,差异有统计学意义(P<0.01)。结论PRP治疗可显著提高临床疗效,降低VSS和VAS评分,改善瘢痕血流灌注量,可推荐用于治疗烧伤后增生性瘢痕。Objective To explore the therapeutic effect of autologous platelet rich plasma(PRP)on hypertrophic scars after burns.Methods 80 patients with hypertrophic scars after burns treated at the Ninth Hospital from September 2016 to June 2023 were randomly divided into an experimental group of 42 cases and a control group of 38 cases.The control group received routine Meek skin transplantation treatment,while the experimental group received PRP combined with Meek skin transplantation treatment.Both groups were followed up for 3 and 6 months to analyze the clinical efficacy,Vancouver Scar Scale(VSS),Pain VAS score,and scar blood flow perfusion between the two groups.Results The total effective rate in the experimental group was higher than that in the control group,and the dif⁃ference was statistically significant(P<0.05).At 3 months of treatment,the thickness,flexibility,and overall score of the experimental group were significantly lower than those of the control group(P<0.05).At 6 months of treatment,the VSS scores and overall score of the experimental group were significantly lower than those of the control group(P<0.05);At 3 and 6 months of treatment,there was a significant differ⁃ence in VAS scores between the experimental group and the control group(P<0.05);at 3 and 6 months of treatment,the scar blood flow perfusion in the experimental group was significantly lower than that in the control group(P<0.01).Conclu⁃sion PRP treatment can significantly improve clinical efficacy,reduce VSS and VAS scores,improve scar blood flow perfu⁃sion,and can be recommended for the treatment of hypertrophic scars after burns.

关 键 词：烧伤 增生性瘢痕 富血小板血浆 治疗 

分 类 号：R644[医药卫生—外科学]