血清TgAb、MCP-1、IL-13水平与桥本甲状腺炎患者预后的关系研究  

The Relationship between Serum TgAb,MCP⁃1,IL⁃13 Levels and Progno⁃sis of Hashimoto's Thyroiditis Patients

作　　者：周娅丽 田雪峰 林毅[3] 施羽 季沈杰 ZHOU Yali;TIAN Xuefeng;LIN Yi;SHI Yu;JI Shenjie(Department of Laboratory,Qidong People's Hospital/Qidong Liver Cancer Prevention and Treatment Research Institute/Qidong Hospital Affiliated to Nantong University,Nantong,Jiangsu 226200,China;Department of Endocrinology,Qidong People's Hospital/Qidong Liver Cancer Prevention and Treatment Research Institute/Qidong Hospital Affiliated to Nantong University,Nantong,Jiangsu 226200,China;Depart-ment of Endocrinology,Shanghai First People's Hospital,Shanghai 200000,China)

机构地区：[1]启东市人民医院启东肝癌防治研究所南通大学附属启东医院检验科,江苏南通226200 [2]启东市人民医院启东肝癌防治研究所南通大学附属启东医院内分泌科,江苏南通226200 [3]上海市第一人民医院内分泌科,上海200000

出　　处：《转化医学杂志》2024年第7期989-993,共5页Translational Medicine Journal

基　　金：南通市卫生健康委员会面上项目(MSZ2023108)。

摘　　要：目的探究甲状腺球蛋白抗体(TgAb)、单核细胞趋化蛋白1(MCP-1)、白细胞介素13(IL-13)水平与桥本甲状腺炎(HT)患者预后的关系。方法选择2020年2月至2023年2月启东市人民医院收治的80例HT患者作为HT组,另选择本院同期53例健康体检者作为对照组。2组均测定血清TgAb、MCP-1、IL-13水平与甲状腺激素水平,比较2组血清TgAb、MCP-1、IL-13水平与甲状腺激素水平,分析HT组患者血清TgAb、MCP-1、IL-13水平与甲状腺激素水平相关性;随访评估患者预后,分析不同预后HT患者血清TgAb、MCP-1、IL-13水平,分析血清TgAb、MCP-1、IL-13水平对预后预测价值。结果HT组患者血清TgAb、MCP-1水平高于对照组,IL-13水平低于对照组,差异有统计学意义(P<0.05);HT组患者三碘甲状腺原氨酸(T3)、游离三碘甲状腺原氨酸(FT3)、总甲状腺素(T4)、游离甲状腺素(FT4)低于对照组,促甲状腺素(TSH)高于对照组,差异有统计学意义(P<0.05);Pearson相关性分析显示,TgAb、MCP-1与T3、FT3、T4、FT4呈负相关(P<0.05),与TSH呈正相关(P<0.05);IL-13与T3、FT3、T4、FT4呈正相关(P<0.05),与TSH呈负相关(P<0.05);80例HT患者采用L-T4疗法治疗,随访1年时患者临床缓解率为77.5%,临床缓解患者血清TgAb、MCP-1水平低于未缓解患者,IL-13水平高于未缓解患者;受试者工作特征曲线显示,血清TgAb、MCP-1、IL-13水平用于预测患者预后曲线下面积(AUC)值分别为0.683、0.674、0.767,三项指标联合AUC值为0.867。结论血清TgAb、MCP-1、IL-13水平与HT患者甲状腺功能关系密切,三项指标用于评估患者预后价值优异。Objective To explore the relationship between thyroglobulin antibody(TgAb),monocyte chemotactic protein⁃1(MCP⁃1),interleukin⁃13(IL⁃13)levels and prognosis of Hashimoto's thyroiditis(HT)patients.Methods A total of Eighty HT patients admitted to the Qidong people's hospital from February 2020 to February 2023 were selected as the ET group,while 53 healthy patients undergoing physical examination in the hospital during the same period were selected as the control group.Serum TgAb,MCP⁃1,IL⁃13 levels and thyroid hormone levels were measured and compared between the two groups,and their correlation was analyzed;Follow⁃up was conducted to evaluate the prognosis of patients,and serum TgAb,MCP⁃1 and IL⁃13 levels of HT patients with different prognosis were analyzed,and their predictive value on prognosis was ana⁃lyzed.Results Compared with the control group,the serum TgAb and MCP⁃1 levels in HT group were higher,while IL⁃13 levels were lower(P<0.05);The triiodothyronine(T3),free triiodothyronine(FT3),total thyroxine(T4)and free thyrox⁃ine(FT4)in HT group were lower than those in the control group,while the thyrostimulating hormone(TSH)was higher(P<0.05);Pearson correlation analysis showed that TgAb and MCP⁃1 were negatively correlated with T3,FT3,T4 and FT4(P<0.05),but positively correlated with TSH(P<0.05),and IL⁃13 was positively correlated with T3,FT3,T4 and FT4(P<0.05),but negatively correlated with TSH(P<0.05);80 patients were treated with L⁃T4 therapy,and the clinical remis⁃sion rate was 77.5%at 1 year follow⁃up.Serum TgAb and MCP⁃1 levels in patients with clinical remission were lower than those in patients without remission,but IL⁃13 levels were higher;The receiver operating characteristic curves showed that the area under the curve(AUC)values of serum TgAb,MCP⁃1 and IL⁃13 levels in predicting the prognosis of patients were 0.683,0.674 and 0.767,respectively,and the combined AUC value of the three indexes was 0.867.Conclusion Serum TgAb,MCP⁃1 and IL⁃13 levels are clo

关 键 词：桥本甲状腺炎 甲状腺球蛋白抗体 单核细胞趋化蛋白1 白细胞介素13 预后 

分 类 号：R25[医药卫生—中医内科学]