ROC曲线评价外周血炎症因子在儿童呼吸道感染中的预测价值  

ROC Curve to Evaluate the Predictive Value of Peripheral Blood Inflam⁃matory Factors in Children with Respiratory Tract Infection

作　　者：刘星[1] 李红 祝金波 吴迪[1] 禹红[1] LIU Xing;LI Hong;ZHU Jinbo;WU Di;YU Hong(Department of Medical Laboratory,Wuhan Hospital of Traditional Chinese Medicine,Wuhan 430014,China)

机构地区：[1]武汉市中医医院检验科,武汉430014

出　　处：《转化医学杂志》2024年第7期1075-1079,共5页Translational Medicine Journal

基　　金：湖北省中医药管理局中医药科研项目(ZY2023F052);武汉市卫健委中医药科研项目(WZ22C69)。

摘　　要：目的研究血清降钙素原(PCT)、淀粉样蛋白A(SAA)及白细胞介素6(IL-6)检测对不同病原感染所致儿童呼吸道感染的评价作用。方法选取2023年1月至2023年5月武汉市中医医院儿科收治的160例呼吸道感染患儿纳入研究,根据感染类型将患儿分为组细菌感染组和病毒感染组,每组80例;另选同期健康体检者50例为对照组。检测并比较3组儿童外周血PCT、SAA及IL-6水平,以受试者工作特征(ROC)曲线分析上述各项指标在儿童呼吸道感染中的诊断效能。结果细菌感染组和病毒感染组PCT、SAA及IL-6水平均高于对照组,且细菌感染组高于病毒感染组,差异有统计学意义(P<0.05)。细菌感染组和病毒感染组PCT、SAA及IL-6阳性率均高于对照组,且细菌感染组高于病毒感染组,差异有统计学意义(P<0.05)。ROC曲线分析结果显示,与病毒性感染患儿比较,细菌性感染患儿的PCT、SAA及IL-6检测诊断曲线下面积、敏感度以及特异度均更高。结论PCT、SAA及IL-6检测应用于差异性病原感染所致儿童上呼吸道感染的诊断价值较高。Objective To investigate the role of serum procalcitonin(PCT),amyloid A(SAA)and interleukin⁃6(IL⁃6)detection respiratory tract infection in children caused by different pathogens.Methods One hundred and sixty chil⁃dren with respiratory tract infection who were admitted to the Department of Pediatrics of Wuhan Hospital of Traditional Chi⁃nese Medicine from January 2023 to May 2023 were selected for the study.According to the type of infection,the patients were divided into a bacterial infection group and a viral infection group,with eighty cases in each group,and 50 healthy sub⁃jects were selected as the control group.The levels of PCT,SAA,and IL⁃6 in peripheral blood of the three groups were detec⁃ted and compared.Receiver Operating Characteristic(ROC)curve was used to analyze the diagnostic efficacy of the above in⁃dexes on respiratory tract infection in children.Results Compared with the control group,PCT,SAA and IL⁃6 levels in the bacterial and viral groups were higher than those in the control group,and the bacterial group was higher than the viral group,the differences were statistically significant(P<0.05).The positive rates of PCT,SAA and IL⁃6 in the bacterial and viral groups were higher than those in the control group,and the bacterial group showed higher rates than the viral group,with sta⁃tistical significance(P<0.05).ROC curve analysis revealed compared with virus⁃infected children,children with bacterial infection had higher areas under the diagnostic curves for PCT,SAA,and IL⁃6,as well as higher sensitivity and specificity.Conclusion The detection of PCT,SAA and IL⁃6 has significant value in diagnosing children with upper respiratory tract in⁃fection caused by different pathogens.

关 键 词：降钙素原 淀粉样蛋白A 白细胞介素6 儿童呼吸道感染 

分 类 号：R725.6[医药卫生—儿科]