补肾接骨汤联合药物外敷对四肢闭合性骨折后急性肿胀患者疼痛及血清骨保护素水平的影响  

Effects of Bushen Jiegu Tang Combined with External Application of Medi⁃cation on Pain and Serum OPG Level in Patients with Acute Swelling after Closed Fracture of Limbs

作　　者：阮峻[1] 李炫莹 RUAN Jun;LI Xuanying(Department of Orthopedics and Traumatology,Foshan Hospital of Traditional Chinese Medicine,Foshan,Guangdong 528000,China)

机构地区：[1]佛山市中医院骨伤科,广东佛山528000

出　　处：《转化医学杂志》2024年第7期1120-1126,共7页Translational Medicine Journal

基　　金：2023年佛山市自筹经费类科技创新项目(2320001007183)。

摘　　要：目的观察补肾接骨汤联合药物外敷辅治四肢闭合性骨折后急性肿胀的效果。方法选择2022年7月至2024年2月佛山市中医院骨伤科收治的四肢闭合性骨折后急性肿胀患者160例,利用随机数表法将患者分为对照组(在保护患肢、局部制动、抬高患肢等康复措施基础上予药物外敷)和研究组(在对照组基础上另予补肾接骨汤),每组80例。比较2组肿胀程度和疼痛程度、血液流变学指标、炎症因子、骨保护素(OPG)、转化生长因子β1(TGF-β1)、成纤维细胞生长因子2(FGF-2)以及骨痂生长情况。结果治疗1周后、治疗2周后、治疗3周后,2组的肿胀程度、疼痛程度、血浆黏度、红细胞压积、肿瘤坏死因子α(TNF-α)、白细胞介素(IL)-1、IL-8小于治疗前(P<0.05),且研究组小于对照组(P<0.05);治疗2周后、治疗3周后,2组的肿胀程度、疼痛程度、血浆黏度、红细胞压积、TNF-α、IL-1、IL-8小于治疗1周后(P<0.05),且研究组小于对照组(P<0.05);治疗3周后,2组的肿胀程度、疼痛程度、血浆黏度、红细胞压积、TNF-α、IL-1、IL-8小于治疗2周后(P<0.05),且研究组小于对照组(P<0.05)。治疗1周后、治疗2周后、治疗3周后,2组的OPG、TGF-β1、FGF-2、骨痂量评分、骨痂密度评分、骨痂边缘评分、断端边缘评分大于治疗前(P<0.05),且研究组大于对照组(P<0.05);治疗2周后、治疗3周后,2组的OPG、TGF-β1、FGF-2、骨痂量评分、骨痂密度评分、骨痂边缘评分、断端边缘评分大于治疗1周后(P<0.05),且研究组大于对照组(P<0.05);治疗3周后,2组的OPG、TGF-β1、FGF-2、骨痂量评分、骨痂密度评分、骨痂边缘评分、断端边缘评分大于治疗2周后(P<0.05),且研究组大于对照组(P<0.05)。结论补肾接骨汤联合药物外敷辅治四肢闭合性骨折后急性肿胀,可减轻肿胀、疼痛,改善血液流变学指标,调节TNF-α、IL-1、IL-8、OPG、TGF-β1、FGF-2,以及促进骨痂生长。Objective To observe the effect of Bushen Jiegu Tang combined with external application of medication in treating acute swelling after closed fracture of limbs.Methods A total of 160 patients with acute swelling after closed fracture of limbs admitted to department of orthopedics and traumatology,Foshan hospital of traditional chinese medicine,from July 2022 to February 2024 were gathered and assigned into a control group(apply medication externally on the basis of rehabilita⁃tion measures such as protecting the affected limb,local immobilization,and raising the affected limb)and a study group(On the basis of the control group,Bushen Jiegu decoction was added)using a digital random table method,with 80 patients in each group.The degree of swelling,degree of pain,hemorheological indicators,inflammatory factors,osteoprotegerin(OPG),transforming growth factor⁃β1(TGF⁃β1),fibroblast growth factor⁃2(FGF⁃2),and callus growth were compared.Results After 1 week,2 weeks,and 3 weeks of treatment,the degree of swelling,pain,plasma viscosity,hematocrit,tumor necrosis factor⁃α(TNF⁃α),interleukin⁃1,and IL⁃8 in both groups were lower than before treatment(P<0.05),and the study group was lower than the control group(P<0.05);after 2 weeks and 3 weeks of treatment,the degree of swelling,pain,plasma viscosity,hematocrit,TNF⁃α,IL⁃1,and IL⁃8 in both groups were lower than those after 1 week of treatment(P<0.05),and the study group was lower than the control group(P<0.05);after 3 weeks of treatment,the degree of swelling,pain,plasma viscosity,hematocrit,TNF⁃α,IL⁃1,and IL⁃8 in both groups were lower than those after 2 weeks of treat⁃ment(P<0.05),and the study group was lower than the control group(P<0.05).After 1 week,2 weeks,and 3 weeks of treatment,the OPG,TGF⁃β1,FGF⁃2,callus volume score,callus density score,callus margin score,and fracture margin score of both groups were higher than before treatment(P<0.05),and the study group was higher than the control group(P<0.05);after 2 weeks and 3 w

关 键 词：补肾接骨汤 药物外敷 四肢闭合性骨折 急性肿胀 疼痛 

分 类 号：R683.4[医药卫生—骨科学]