沙库巴曲缬沙坦联合重组人脑钠肽治疗心力衰竭的临床疗效研究  

Clinical Efficacy of Sacubitril Valsartan Combined with Recombinant Human Brain Natriuretic Peptide in the Treatment of Heart Failure

作　　者：朱捷 李迪 张晶晶 ZHU Jie;LI Di;ZHANG Jingjing(Department of Cardiovascular,Zhangjiagang Aoyang Hospital,Zhangjiagang,Jiangsu 215600,China)

机构地区：[1]张家港澳洋医院心血管内科,江苏张家港215600

出　　处：《转化医学杂志》2024年第7期1141-1144,共4页Translational Medicine Journal

基　　金：张家港市卫生健康委科研项目(ZJGQNKJ202255)。

摘　　要：目的 本研究旨在探讨重组人B型脑钠肽(rhBNP)与沙库巴曲缬沙坦(SV)联合治疗急性心力衰竭的临床疗效及其对炎症因子和氧化应激指标的影响。方法 选取2020年3月至2023年3月张家港澳洋医院心血管内科收治的202例急性心力衰竭患者,按随机数表法将患者分为观察组和对照组,每组101例。对照组接受心力衰竭标准治疗,观察组在对照组的基础上联合使用rhBNP和SV。比较2组治疗前后心功能、炎症因子和氧化应激水平。结果观察组治疗有效率为91.09%,显著高于对照组的79.21%,差异有统计学意义(P=0.023)。治疗后,观察组心脏指数、左心室射血分数显著提高,心率显著降低(P<0.01)。治疗后,观察组炎症因子白细胞介素6和肿瘤坏死因子α显著降低,氧化应激指标丙二醛显著下降,谷胱甘肽过氧化物酶显著升高,差异有统计学意义(P<0.05)。结论RhBNP与SV联合治疗急性心力衰竭患者,能够显著提高疗效,改善心功能和心肌损伤,同时有效调节炎症反应和氧化应激水平,具有良好的临床应用前景。Objective The aim of this study was to investigate the clinical efficacy of recombinant human B⁃type brain natriuretic peptide(rhBNP)in combination with sacubitril valsartan(SV)in the treatment of acute heart failure and its effect on inflammatory factors and oxidative stress indicators.Methods 202 patients with acute heart failure who were hospi⁃talised in the Department of cardiology of department of cardiovascular,Zhangjiagang Aoyang hospital,from March 2020 to March 2023 were selected and divided into the observation group(n=101)and the control group(n=101)according to the random number table method.The control group received standard treatment for heart failure,and the observation group used rhBNP and SV in combination on this basis.Cardiac function,inflammatory factors and oxidative stress levels were assessed before and after treatment,and statistically analysed.Results The effective rate of treatment in the observation group was 91.09%,which was significantly higher than that of 79.21%in the control group(P=0.023).After treatment,the cardiac index and left ventricular ejection fraction of the observation group were significantly improved,and the heart rate was signifi⁃cantly reduced(P<0.01).The inflammatory factors IL⁃6 and TNF⁃αwere significantly reduced,the oxidative stress indica⁃tor MDA was significantly decreased,and GSH⁃Px was significantly increased in the observation group after treatment(P<0.05).Conclusion The combination of rhBNP and SV in the treatment of patients with acute heart failure can significantly improve the efficacy,improve cardiac function and myocardial injury,as well as effectively regulate the level of inflammatory response and oxidative stress,which has a good prospect for clinical application.

关 键 词：沙库巴曲缬沙坦 重组人脑钠肽 心力衰竭 联合治疗 临床疗效 

分 类 号：R541[医药卫生—心血管疾病]