Photothermal lanthanide nanomaterials: From fundamentals to theranostic applications  

作　　者：Zhuo Li Jiacheng Gong Shan Lu Xingjun Li Xiaobo Gu Jin Xu Jawairia Umar Khan Dayong Jin Xueyuan Chen 

机构地区：[1]State Key Laboratory of Structural Chemistry,Fujian Key Laboratory of Nanomaterials,and CAS Key Laboratory of Design and Assembly of Functional Nanostructures,Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences,Fuzhou,China [2]Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China,Fuzhou,China [3]University of Chinese Academy of Sciences,Beijing,China [4]College of Chemistry and Materials Science,Fujian Normal University,Fuzhou,China [5]School of Physical Science and Technology,ShanghaiTech University,Shanghai,China [6]Institute for Biomedical Materials&Devices(IBMD),Faculty of Science,University of Technology Sydney,Sydney,Australia

出　　处：《BMEMat(BioMedical Engineering Materials)》2024年第4期1-17,共17页生物医学工程材料(英文)

基　　金：National Key Research and Development Program of China,Grant/Award Number:2022YFB3503700;National Natural Science Foundation of China,Grant/Award Numbers:12174392,22175179,22135008,U22A20398;Natural Science Foundation of Fujian Province,Grant/Award Numbers:2021I0040,2022I0035,2021L3024,2021J01524;Self-deployment Project Research Program of Haixi Institutes,Chinese Academy of Sciences,Grant/Award Numbers:CXZX-2022-GH10,CXZX-2022-GS01。

摘　　要：Photothermal lanthanide nanomaterials with unique photophysical properties have been innovatively explored for diagnostics and non‐invasive therapies,and hold great promise for precision theranostics.In this review,we start from the basic principles of excited‐state dynamics and provide a thorough comprehension of the main pathways for photothermal conversion in lanthanide nanocrystals.Aspects influencing the photothermal effect such as lanthanide‐doping concentration,particle size,and crystal structure have been fully discussed.Hybrid strategies for the design of efficient lanthanide‐based photothermal agents,including dye sensitization to break the absorption limit and semiconductor combination to add cross‐relaxation pathways,have also been summarized.Furthermore,we highlight the cutting‐edge applica-tions of photothermal lanthanide nanoplatforms with optical diagnosis and temperature feedback in photothermia‐associated theranostics.Lastly,the current challenges and future efforts for clinical applications are proposed.This review is expected to offer a better understanding of photothermal mechanisms and inspire efforts for designing versatile lanthanide theranostic nanoplatforms.

关 键 词：lanthanide nanomaterials optical imaging photothermal mechanism photothermal therapy temperature feedback THERANOSTICS 

分 类 号：O62[理学—有机化学]