Triggerable biomaterials-based osteomyelitis theranostics  

作　　者：Lei Li Yue Yin Shengchang Zhang Junyuan Yang Pei Li Huaijuan Zhou Jinhua Li 

机构地区：[1]School of Medical Technology,Beijing Institute of Technology,Beijing,China [2]Center for Advanced Biotechnology&Medicine,Rutgers University,Piscataway,USA [3]Advanced Research Institute of Multidisciplinary Sciences,Beijing Institute of Technology,Beijing,China

出　　处：《BMEMat(BioMedical Engineering Materials)》2024年第4期49-67,共19页生物医学工程材料(英文)

基　　金：The authors sincerely acknowledge the financial support from the National Natural Science Foundation of China(52302343);Beijing Institute of Technology Teli Young Fellow Program(RCPT-20220029);the Beijing Institute of Technology Research Fund Program for Young Scholars(XSQD-6120220130,XSQD-202213001).

摘　　要：The emergence of multidrug-resistant bacteria poses a significant challenge in the treatment of osteomyelitis,rendering traditional antibiotic treatment strategies inadequate in terms of achieving a complete cure.In recent years,triggerable biomaterial-based,antibiotic-free osteomyelitis treatment strategies have rapidly evolved,demonstrating excellent bactericidal effects.Triggerable biomaterials-based osteomyelitis theranostics encompass physical signal response strategies and host immune modulation approaches.These strategies can be effective against drug-resistant bacteria,circumventing the gradual acquisition of resistance that often accompanies traditional antibiotic treat-ment.Additionally,the inherent physical properties of the triggerable bio-materials facilitate the precise imaging of osteomyelitis.There is no doubt that triggerable biomaterial-mediated,antibiotic-free therapies are emerging as a trend,which is critically important in combating multidrug-resistant bacteria-induced osteomyelitis.In this review,we summarize the latest advances in osteomyelitis treatment strategies from both pathogen-directed and host-directed perspectives.The design regimens and specific action mechanisms of triggerable biomaterial-based nanoplatforms are also clarified.Finally,we outline the challenges faced by various antibiotic-free therapies and provide an outlook on the prospects for synergistic interactions.

关 键 词：antibiotic-free host-directed therapeutics OSTEOMYELITIS pathogen-directed therapeutics precise diagnosis 

分 类 号：TP3[自动化与计算机技术—计算机科学与技术]