药物涂层球囊在下肢动脉粥样硬化闭塞症治疗中的应用现状与未来展望  

Current status and future prospects of drug-coated balloons in the treatment of lower extremity arteriosclerosis obliterans

作　　者：刘斌[1] 桂亮[2] 邹君杰[2] LIU Bin;GUI Liang;ZOU Junjie(The Second Clinical College of Nanjing Medical University,Nanjing 210029,China;Department of Vascular Surgery,the First Affiliated Hospital of Nanjing Medical University/Jiangsu Provincial People's Hospital,Nanjing 210029,China)

机构地区：[1]南京医科大学第二临床学院,江苏南京210029 [2]南京医科大学附属第一医院/江苏省人民医院血管外科,江苏南京210029

出　　处：《中国普通外科杂志》2024年第12期2091-2098,共8页China Journal of General Surgery

基　　金：中国博士后科学基金资助项目(2023M731408);江苏省卓越博士后基金资助项目(2023ZB640);江苏省自然科学基金资助项目(BK20230731);江苏省科教能力提升工程基金资助项目(江苏省医学重点学科,ZDXK202222)。

摘　　要：随着外周血管介入技术与器具的不断进步,药物涂层球囊(DCB)作为一种具有潜力的治疗工具,在下肢动脉疾病的腔内治疗领域已经引起了广泛关注。下肢动脉粥样硬化闭塞症(LEASO)是下肢动脉疾病中最常见的类型,也是DCB技术的重要适应证之一。尽管DCB在股腘病变治疗上取得了显著的进展,但其在下肢动脉某些特定病变,如慢性肢体威胁性缺血、支架内再狭窄等的疗效方面,仍存在一些争议和挑战。本文通过对相关临床研究进行总结与分析,评估DCB在LEASO治疗中的应用情况、安全性、临床疗效以及未来发展方向,为临床实践提供更深入的理解和参考。With the continuous advancement of peripheral vascular interventional techniques and devices,drugcoated balloons(DCBs)have emerged as a promising therapeutic tool,garnering significant attention in endovascular treatment for lower extremity arterial diseases.Lower extremity arteriosclerosis obliterans(LEASO)is the most common type of lower extremity arterial disease and one of the key indications for DCB technology.While DCBs have achieved remarkable progress in treating femoropopliteal lesions,their efficacy in specific lower extremity arterial conditions,such as chronic limb-threatening ischemia and in-stent restenosis,remains controversial and challenging.This article summarizes and analyzes relevant clinical studies to evaluate the application,safety,clinical efficacy,and future directions of DCBs in treating LEASO,providing deeper insights and guidance for clinical practice.

关 键 词：动脉闭塞性疾病 下肢 药物涂层球囊 综述 

分 类 号：R654.3[医药卫生—外科学]