Prognostic value of hs-CR, NT-pro-BNP combined with GRACE score for short-term MACEs after PCI in STEMI patients  

作　　者：WU Jiao 

机构地区：[1]Department of Emergency,The First Affiliated Hospital,Hengyang Medical School,University of South China,Hengyang,421000,China

出　　处：《South China Journal of Cardiology》2024年第4期232-237,共6页岭南心血管病杂志(英文版)

摘　　要：Background ST-elevated myocardial infarction(STEMI) is a common type of acute myocardial infarction with high morbidity, disability and mortality, which seriously threatens the life and health of patients. Percutaneous coronary intervention(PCI) is the preferred treatment for STEMI, which can quickly open blocked coronary arteries and restore myocardial blood perfusion, thus significantly improving the clinical symptoms and prognosis of patients. However, in clinical practice, STEMI patients still face a series of adverse events after PCI, major adverse cardiovascular events(MACEs) are predominant. Therefore, in order to accurately evaluate the short-term MACE after PCI in STEMI patients, it is particularly important to explore more sensitive and specific predictors. Methods Clinical data of 150 STEMI patients admitted to our hospital from June 2021 to May 2024 were retrospectively analyzed, and they were divided into MACEs group(n=42) and non-MACEs group(n=108) according to whether they developed MACEs within 6 months after PCI. The predictive values of highly sensitive C-reactive protein(hs-CRP), N-terminal pro-B-type natriuretic peptide(NT-pro-BNP), the Global Registry of Acute Coronary Events(GRACE) score and synthetic analysis for short-term MACEs after PCI in STEMI patients were respectively analyzed. Either GRACE score >140, hs-CRP level >3 mg/m L or NT-pro-BNP level >1000 pg/m L was considered positive. Synthetic analysis was defined as positive when at least two of the above indicators were positive. Multivariable logistic regression and receiver operation characteristic(ROC) analysis were applied to analyze prognostic values of hs-CR, NT-pro-BNP,GRACE score and synthetic analysis respectively for short-term MACEs after PCI in STEMI patients. Results The level of hs-CRP, NT-pro-BNP and GRACE score in MACEs group were higher than non-MACEs group(P<0.05). Logistic regression analysis showed that hs-CRP, NT-proBNP and GRACE score were all independent risk factors for short-term MACEs after PCI in STEMI pati

关 键 词：ST-segment elevation myocardial infarction Percutaneous coronary intervention Highly sensitive C-reactive protein N-terminal pro-B-type natriuretic peptide Global Registry of Acute Coronary Events 

分 类 号：R54[医药卫生—心血管疾病]