乙肝肝纤维化中西医研究进展  

Progress of traditional Chinese and Western medicine research on chronic hepatitis B hepatic fibrosis

作　　者：俞佳雯 周薏 [加拿大]林天龙[3] 阙任烨 YU Jiawen;ZHOU Yi;LIN Tianlong;QUE Renye(Shanghai Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200082,China;Shanghai University of Traditional Chinese Medicine Affiliated Hospital of Traditional Chinese Medicine,Shanghai 200071,China;Renji Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200001,China)

机构地区：[1]上海中医药大学附属上海中西医结合医院,上海200082 [2]上海中医药大学附属上海中医医院,上海200071 [3]上海交通大学附属仁济医院,上海200001

出　　处：《陕西中医》2025年第2期273-276,280,共5页Shaanxi Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(82204816);上海市青年科技英才扬帆计划项目(19YF1445200);上海市卫生健康委员会中发办青年基金资助项目(2018LQ016);上海中医药大学科研项目(18LK074)。

摘　　要：肝纤维化(HF)是指各种病因导致的慢性肝脏疾病发展过程中,肝细胞反复受损后过度修复的一种病理改变,以细胞外基质弥漫性过度沉积及异常分布为特征。肝纤维化早期无显著的临床症状,易被忽略,若未得到有效干预,最终可导致肝硬化甚至肝癌的发生,严重危害人们的生命安全。除针对病因治疗以外,使用药物及时有效地逆转肝纤维化,是防治各种慢性肝病的关键策略。本文针对慢乙肝肝纤维化的西医流行病学、发病机制、检测手段、药物治疗以及中医病因病机、辨证施治的研究进展作一综述,以期为慢乙肝肝纤维化的中西医结合防治提供一定的参考价值。Hepatic fibrosis(HF)is a pathological change caused by excessive repair of liver cells after repeated damage in the development of chronic liver diseases caused by various causes.It is characterized by widespread over-accumulation and irregular dispersion of extracellular matrix.In the early stage of HF,it is easy to be ignored because there is no significant clinical symptoms.If there is no effective intervention,it can eventually lead to cirrhosis and even liver cancer,seriously endangering people’s life safety.In addition to the etiological treatment,the use of drugs to reverse HF in a timely and effective manner is a key strategy for the prevention and treatment of various chronic liver diseases.This article reviews the progress of Western medicine epidemiology,pathogenesis,detection methods,drug treatment,Chinese medicine etiology,machanism and dialectical argumentation of chronic hepatitis B hepatic fibrosis,in order to provide some reference value for the prevention and treatment of chronic hepatitis B hepatic fibrosis.

关 键 词：肝纤维化 慢性乙型肝炎 辨证论治 抗病毒 中药联合 进展研究 

分 类 号：R657.31[医药卫生—外科学]