辅助生殖技术中双扳机应用的研究进展  

Progress in the Application of Dual Trigger in Assisted Reproductive Technology

作　　者：姚相宜 刘培昊(审校) YAO Xiang-yi;LIU Pei-hao(Institute of Women,Children and Reproductive Health,Shandong University,Jinan 250012,China)

机构地区：[1]山东大学妇儿与生殖健康研究院,济南250012

出　　处：《国际生殖健康/计划生育杂志》2025年第1期36-40,共5页Journal of International Reproductive Health/Family Planning

摘　　要：在辅助生殖技术(assisted reproductive technology,ART)的控制性超促排卵(controlled ovarian hyperstimulation,COH)过程中,适当扳机方式的选择至关重要。随着对人绒毛膜促性腺激素(human chorionic gonadotropin,hCG)扳机及促性腺激素释放激素激动剂(gonadotropin-releasing hormone agonist,GnRH-a)扳机利弊研究的不断深入,双扳机即GnRH-a联合hCG扳机被提出并应用于临床,以期减少卵巢过度刺激综合征(ovarian hyperstimulation syndrome,OHSS)发生率,改善ART结局。然而,由于不同患者在年龄、卵巢储备、体质量指数(body mass index,BMI)等方面存在异质性,双扳机应用于卵巢高反应、正常反应及低反应人群可能产生不同程度的效果。综述双扳机的最新研究进展,以期为临床不同卵巢反应患者扳机方式的选择提供参考,并探讨了双扳机需要继续深入研究的方向,如扳机药物剂量、取卵时机、个体化黄体支持方案及新扳机方式的探索。The choice of appropriate trigger methods in the controlled ovarian hyperstimulation(COH)of assisted reproductive technology(ART)is crucial.With the in-depth study of the pros and cons of human chorionic gonadotropin(hCG)trigger and gonadotropin-releasing hormone agonist(GnRH-a)trigger,the dual trigger,defined as the combined trigger with GnRH-a and hCG,was proposed and applied in clinical practice in order to reduce the incidence of ovarian hyperstimulation syndrome(OHSS)and improve the outcome of ART.However,due to the heterogeneity of different patients in age,ovarian reserve,body mass index(BMI),etc.,the application of dual trigger may produce varying degrees of effect,in the patients with high,normal and low ovarian response.This review summarizes the research progress of dual trigger,so as to provide a reference for the selection of trigger methods in the patients with different ovarian responses.We also discuss the directions for further research on the dual trigger,such as trigger doses,the timing of oocyte retrieval,the individualized luteal phase support,and new trigger methods.

关 键 词：超排卵 卵巢过度刺激综合征 生殖技术 辅助 绒毛膜促性腺激素 促性腺激素释放激素激动剂 双扳机 

分 类 号：R714.8[医药卫生—妇产科学]