微小RNA参与多囊卵巢综合征胰岛素抵抗的研究进展  

Advancements in Research on MicroRNAs Related to Insulin Resistance in Polycystic Ovary Syndrome

作　　者：贾声晓 孙淼[1] 匡洪影(审校)[1] 徐博雅 JIA Sheng-xiao;SUN Miao;KUANG Hong-ying;XU Bo-ya(Department of GynecologyⅡ,First Affilliated Hospital,Heilongjiang University of Chinese Medicine,Harbin 150040,China;Department of Public Health,The 186th Regiment Hospital of the 10th Division of Xinjiang Production and Construction Corps,Beitun 836801,Xinjiang Uygur Autonomous Region,China)

机构地区：[1]黑龙江中医药大学附属第一医院妇科二科,哈尔滨150040 [2]新疆生产建设兵团第十师一八六团医院公共卫生科

出　　处：《国际生殖健康/计划生育杂志》2025年第1期59-64,共6页Journal of International Reproductive Health/Family Planning

基　　金：国家自然科学基金(82174195);黑龙江省中医药科研项目(ZHY2023-087)。

摘　　要：胰岛素抵抗(insulin resistance,IR)是多囊卵巢综合征(polycystic ovary syndrome,PCOS)普遍的临床表现之一,同时在PCOS的病理过程中也占据着至关重要的位置。PCOS和IR密切相关,互为病因,二者相互作用形成恶性循环。近年来,关于微小RNA(microRNA,miRNA)在PCOS代谢紊乱病因学方面的研究逐渐深入,miRNA的表达水平在一定程度上与PCOS-IR的发生密切相关。总结近年来关于miRNA参与PCOS-IR的病理过程和致病机制等方面的研究进展。Insulin resistance(IR)characterizes not only a universal clinical feature of polycystic ovary syndrome(PCOS),but also serves a significant role in its pathophysiology.PCOS and IR are closely related and mutually cause each other.The interaction between IR and PCOS creates a detrimental cycle.There was substantial progress in the study of microRNAs(miRNAs)roles in PCOS-linked metabolic disturbances.The degree of miRNAs expression is intrinsically associated with PCOS-IR.In this paper,we discuss the miRNAs-related etiopathogenesis of PCOS-IR.

关 键 词：多囊卵巢综合征 微RNAS 胰岛素抵抗 磷酸肌醇3-激酶类 原癌基因蛋白质c-akt 胰岛素受体底物蛋白质类 

分 类 号：R711.75[医药卫生—妇产科学]