2型糖尿病与小肠细菌过度生长关系的系统性分析  

Meta-analysis of relationship between type 2 diabetes mellitus and small intestinal bacterial overgrowth

作　　者：尹文琴 石庚生 林松 张林落 罗静 YIN Wenqin;SHI Gengsheng;LIN Song;ZHANG Linluo;LUO Jing(School of Medical Technology,Jiangsu College of Nursing,Huai'an 223003,China)

机构地区：[1]江苏护理职业学院医学技术学院,江苏淮安223003 [2]江苏护理职业学院医学基础部,江苏淮安223003 [3]南京医科大学附属淮安第一医院临床营养科,江苏淮安223300 [4]江苏护理职业学院康复学院,江苏淮安223003

出　　处：《山东医药》2025年第1期91-95,共5页Shandong Medical Journal

基　　金：江苏省高校自然科学研究面上项目(23KJD360001);江苏省高校哲学社会科学研究一般项目(2024SJYB1446)。

摘　　要：目的系统性分析2型糖尿病(T2DM)与小肠细菌过度生长(SIBO)的关系。方法计算机检索PubMed、EMBASE、Web of Science、Cochrane Library、中国知网、万方数据库、维普数据库中关于T2DM和SIBO的文献,检索时间为建库至2024年8月,根据制定的纳入和排除标准筛选文献。对纳入的文献进行Meta分析,比较T2DM患者与健康对照者的SIBO发生风险。为探究异质性来源,进行研究设计、研究对象所处大陆及研究质量的亚组分析。结果共纳入18篇文献,5694例研究对象。Meta分析结果显示,与健康对照者比较,T2DM患者发生SIBO的风险增加(OR=3.18,95%CI为2.24~4.53,P<0.001)。亚组分析结果显示,T2DM患者在病例对照研究中发生SIBO的风险增加(OR=6.56,95%CI为3.96~10.86,P<0.001),在横断面研究中发生SIBO的风险亦增加(OR=2.05,95%CI为1.38~3.06,P<0.001);且病例对照研究中T2DM发生SIBO的风险高于横断面研究;亚洲T2DM患者发生SIBO的风险增加(OR=5.85,95%CI为3.09~11.08,P<0.001),欧洲T2DM患者发生SIBO的风险亦增加(OR=2.58,95%CI为1.41~4.73,P=0.002),而北美T2DM患者SIBO的发生风险无显著差异(OR=1.67,95%CI为0.77~3.62,P=0.193),亚洲T2DM患者发生SIBO的风险高于欧洲患者;高质量研究中T2DM患者发生SIBO的风险增加(OR=5.06,95%CI为2.40~10.66,P<0.001),低质量研究中T2DM患者发生SIBO的风险亦增加(OR=2.72,95%CI为1.82~4.09,P<0.001),且高质量研究中T2DM发生SIBO的风险高于低质量研究。结论T2DM患者发生SIBO的风险高于一般健康人群,亚洲T2DM患者发生SIBO的风险高于欧洲患者。Objective To systematically analyse the relationship between type 2 diabetes mellitus(T2DM)and small intestinal bacterial overgrowth(SIBO).Methods A computerised search of PubMed,EMBASE,Web of Science,Cochrane Library,China National Knowledge Infrastructure,Wanfang Database,and VIP Database for literature on T2DM and SIBO was conducted from the time of library construction to August 2024,and the literature was screened according to the established inclusion and exclusion criteria.Meta-analysis of the included literature was performed to compare the risk of SIBO between patients with T2DM and healthy controls.To explore sources of heterogeneity,subgroup analyses of study design,continent of study population and study quality were performed.Results A total of 18 publications with 5,694 study subjects were included.Meta-analysis results showed the risk of SIBO in patients with T2DM increased in comparison with that of the healthy controls(OR=3.18,95%CI:2.24-4.53,P<0.001).Subgroup analyses showed that patients with T2DM had an increased risk of SIBO in case-control studies(OR=6.56,95%CI:3.96 to 10.86,P<0.001),as well as in cross-sectional studies(OR=2.05,95%CI:1.38 to 3.06,P<0.001);and T2DM patients had a higher risk of SIBO in case-control studies than in cross-sectional studies;Asian T2DM patients had an increased risk of SIBO(OR=5.85,95%CI:3.09 to 11.08,P<0.001),as well as European T2DM patients(OR=2.58,95%CI:1.41 to 4.73,P=0.002),whereas there was no significant difference in the risk of SIBO in North American T2DM patients(OR=1.67,95%CI:0.77 to 3.62,P=0.193),and the risk of SIBO was higher in Asian T2DM patients than in European patients;the risk of SIBO increased in T2DM patients in high-quality studies(OR=5.06,95%CI:2.40 to 10.66,P<0.001),the risk of SIBO increased in T2DM patients in low-quality studies(OR=2.72,95%CI:1.82 to 4.09,P<0.001),and the risk of SIBO in T2DM patients in the high-quality studies was higher than that in low-quality studies.Conclusion The risk of SIBO was higher in T2DM patients than in

关 键 词：小肠细菌过度生长 2型糖尿病 META分析 

分 类 号：R587.1[医药卫生—内分泌]