Benefits of natural edible ingredients in epidermal permeability barrier function  

作　　者：Dongyun Lei Xiaojie Liu Ting Zhang Jiaxing Chen Junling Zhang Litao Zhang 

机构地区：[1]Department of Dermatology,Tianjin Institute of Integrative Dermatology,Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital,Tianjin 300120,China [2]Tianjin University of Traditional Chinese Medicine,Tianjin 300120,China

出　　处：《Chinese Medical Journal》2024年第23期2868-2870,共3页中华医学杂志(英文版)

基　　金：supported by a grant from the Tianjin Municipal Health Commission(No.TJW2022QN088).

摘　　要：The crucial role of the epidermal function in the regulation of cutaneous and extracutaneous functions has been well demonstrated over the past decades.Epidermal permeability barrier dysfunction enhances epidermal DNA and lipid synthesis,and cutaneous and systemic inflammation.[1,2]Conversely,improvement in epidermal permeability barrier function inhibits epidermal lipid synthesis,cytokine production,and epidermal proliferation in barrier-disrupted skin.[1,2]Similarly,reduced stratum corneum hydration(SCH)levels can negatively impact epidermal function and increase cytokine levels in the circulation.[3,4]Correspondingly,improvement in epidermal function lowers the circulating levels of proinflammatory cytokines in addition to alleviation and prevention of the relapse of inflammatory skin disorders such as psoriasis.[2,5,6]Interestingly,improvement in epidermal function also mitigates the progression of cognitive impairment in the elderly.[7]Taken together,the evidence indicates the regulatory role of epidermal function in cutaneous and extracutaneous functions.Thus,improvement in epidermal function can benefit the overall human health.

关 键 词：prevention function BARRIER 

分 类 号：R33[医药卫生—人体生理学]