游离替考拉宁血药浓度监测及其影响因素  

Blood Concentration Monitoring and Influencing Factors of Unbound Teicoplanin

作　　者：王晶[1,2] 吴泽君 金路 罗雪梅[1] 朱怀军[1,2] WANG Jing;WU Zejun;JIN Lu;LUO Xuemei;ZHU Huaijun(Department of Pharmacy,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210008,China;Nanjing Medical Center for Clinical Pharmacy,Nanjing 210008,China)

机构地区：[1]南京大学医学院附属鼓楼医院药学部,南京210008 [2]南京临床药学中心,南京210008

出　　处：《医药导报》2025年第2期293-298,共6页Herald of Medicine

基　　金：南京药学会——常州四药医院药学科研基金资助课题(2022YX006);江苏省研究型医药学会精益化用药科研基金资助项目(JY202231)。

摘　　要：替考拉宁是目前临床上治疗多重耐药金黄色葡萄球菌和肠球菌感染疾病的首选药物之一。其血浆蛋白结合率较高,绝大部分药物进入人体后与蛋白结合,只有部分药物以游离形式存在,但仅游离药物可透过生物膜,进入靶组织发挥疗效,因此对游离替考拉宁血药浓度进行监测具有个体化用药指导价值和重要的临床意义。该文总结对比游离替考拉宁药物浓度测定方法并分析其优劣势,并在此基础上对影响游离替考拉宁药物浓度的可能因素进行分析,为后期开发新的游离替考拉宁浓度检测方法及基于游离浓度提供更精准的个体化用药方案提供参考。Teicoplanin,currently one of the preferred drugs for treating infections caused by multidrug-resistant Staphylococcus aureus and Enterococcus in clinical practice,has a high plasma protein binding rate.Most of the drug binds to protein after entering the body,only a portion of the drug exists in a free form.Since the free drug can pass through biological membranes and enter the target tissue to exert its therapeutic effect,monitoring the free teicoplanin blood concentration is clinically important and plays a role in guiding individualized drug therapy.This article summarizes and compares the current methods for determining the concentration of free teicoplanin in the blood,and analyzes their advantages and disadvantages.Based on this,it analyzes the possible factors affecting the concentration of free teicoplanin in the blood,providing a reference for the development of new methods for detecting free teicoplanin concentration and providing more accurate individualized medication plans based on free concentration.

关 键 词：替考拉宁 血药浓度监测 游离药物浓度 

分 类 号：R978.1[医药卫生—药品]