来那度胺致严重周围神经病变1例  

A Case of Severe Lenalidomide-induced Peripheral Neuropathy

作　　者：王核梅 闫新星 刘建芳[1] 刘加强[2] 曾敏 WANG Hemei;YAN Xinxing;LIU Jianfang;LIU Jiaqiang;ZENG Min(Department of Pharmacy,the People's Hospital of Rizhao City,Shandong Province,Rizhao 276800,China;Department of Hematology,the People's Hospital of Rizhao City,Shandong Province,Rizhao 276800,China;Department of Pharmacy,the Affiliated Hospital of Southwest Medical University,Luzhou 646000,China)

机构地区：[1]山东省日照市人民医院药学部,日照276800 [2]山东省日照市人民医院血液科,日照276800 [3]西南医科大学附属医院药学部,泸州646000

出　　处：《医药导报》2025年第2期305-308,共4页Herald of Medicine

基　　金：西南医科大学附属医院博士科研启动基金资助项目(21028);泸州市科技局应用(基础)研究(2024JYJ021);教育部代谢性心血管疾病医药基础研究创新中心基础研究(一般项目)(xnykdxcxzx2024-10)。

摘　　要：1例患者确诊弥漫大B细胞淋巴瘤1个月、肢体麻木1周入院治疗。入院后给予维生素B 1片、甲钴胺片营养神经对症治疗后肢体麻木症状较前好转,后给予利妥昔单抗注射液、来那度胺胶囊和醋酸泼尼松片方案化疗后肢体麻木症状较前愈发明显,临床药师结合患者既往用药史并查阅资料分析,该患者的肢体麻木为来那度胺引起的周围神经病变。The patient was admitted to the hospital with a diagnosis of diffuse large B-cell lymphoma for one month,accompanied by limb numbness for one week.Upon admission,the patient was initially prescribed vitamin B 1 and mecobalamin for symptomatic relief,which led to an improvement in the symptoms of limb numbness.Subsequently,the patient was administered chemotherapy consisting of rituximab,lenalidomide,and prednisone.However,following the initiation of chemotherapy,the symptoms of limb numbness became more severe.After review of the patient's medication history and analysis of relevant data,the clinical pharmacist suggested that the patient's limb numbness was caused by lenalidomide-induced peripheral neuropathy.

关 键 词：来那度胺 淋巴瘤 周围神经病变 肢体麻木 

分 类 号：R979.19[医药卫生—药品] R969.3[医药卫生—药学]