膜分离法和醇沉法制备复方板蓝根颗粒的对比研究  

Comparison of Membrane Separation Method and Alcohol Precipitation Method as Purification Process of Compound Banlangen Granules

作　　者：董福越 赖娟娟[1] 利幼[1] 严曾豪 郭海彪[1] 王德勤[1] Dong Fuyue;Lai Juanjuan;Li You;Yan Zenghao;Guo Haibiao;Wang Deqin(Hutchison Whampoa Guangzhou Baiyunshan Chinese Medicine Company Limited,Guangzhou,510515,China)

机构地区：[1]广州白云山和记黄埔中药有限公司,广东广州510515

出　　处：《成都中医药大学学报》2025年第1期42-46,共5页Journal of Chengdu University of Traditional Chinese Medicine

基　　金：国家中医药管理局国际合作司中医药国际合作专项(基地类项目)(0610-2240NF021548);广州市科协青年科技人才托举项目(QT-2023-050)。

摘　　要：目的:评价复方板蓝根颗粒基于醇沉法和膜分离法的制备工艺。方法:本研究以复方板蓝根提取液和成品颗粒为研究对象,以提取液的物理常数pH值、电导率、固含物去除率和成品颗粒的指标性成分尿苷、鸟苷、腺苷和(R,S)-告依春的含量为指标,评价制备复方板蓝根颗粒醇沉法和膜分离法2种不同精制工艺。结果:与醇沉法相比,经膜分离法(200 nm陶瓷膜,进口压力为0.2 MPa)处理后的提取液,其电导率和固含物去除率下降更多;经膜分离法制备的复方板蓝根颗粒,其指标性成分鸟苷、尿苷、(R,S)-告依春、腺苷的含量也更高,且服用量更少。结论:相比醇沉法,膜分离法制备复方板蓝根颗粒具有操作简便、耗能少,有效成分保留量高、服用量少的优点。Objective:To evaluate the preparation process of compound Isatilangen granules based on alcohol precipitation and membrane separation.Methods:Two different refining processes of compound Isatidis root granules prepared by alcohol precipitation and membrane separation were evaluated by the physical constant pH value of the extract,electrical conductivity,removal rate of solid content of the extract and the index components of uridine,guanosine,adenosine and(R,S)-goitrin of the finished granules.Results:Compared with the alcohol precipitation method,the conductivity and solid removal efficiency of the extracts treated by the membrane separation method(200 nm ceramic membrane,inlet pressure 0.2 MPa)decreased more.The content of index components guanosine,uridine,(R,S)-goitrin and adenosine in compound Isatilangen granules prepared by membrane separation method was also higher,and the dosage was less.Conclusion:Compared with the alcohol precipitation method,the membrane separation method has the advantages of simple operation,less energy consumption,higher retention of active ingredients,and less consumption.

关 键 词：膜分离法 醇沉法 复方板蓝根 陶瓷膜 

分 类 号：R283[医药卫生—中药学] R282[医药卫生—中医学]