孕晚期可溶性细胞间黏附分子-1、纤维蛋白原、胎盘生长因子与胎盘早剥关系  

Correlation between the levels of the soluble inter-cellular adhesion molecule-l,fibrinogen and placental growth factor of pregnant women during the third trimester of pregnancy and their placental abruption

作　　者：庄玉玉 林莹莹 范冬梅 ZHUANG Yuyu;LIN Yingying;FAN Dongmei(Qingdao Women and Children's Hospital,Qingdao,Shandong Province,266000)

机构地区：[1]青岛市妇女儿童医院,266000

出　　处：《中国计划生育学杂志》2025年第1期174-178,共5页Chinese Journal of Family Planning

摘　　要：目的:探讨孕晚期血可溶性细胞间黏附分子-1(sICAM-1)、纤维蛋白原(FIB)、胎盘生长因子(PLGF)水平与胎盘早剥(PA)发生关系。方法:选择2020年1月-2024年3月本院产前检查疑似PA的孕妇200例为研究对象,以产后诊断为金标准分为PA组(150例)、非PA组(50例,正常分娩)。收集入选孕妇临床资料,检测两组血PLGF、FIB、sICAM-1水平,比较不同病情分级PA孕妇PLGF、FIB、sICAM-1水平,Spearman分析PLGF、FIB、sICAM-1与PA严重程度分级的相关性,受试者工作特征(ROC)曲线分析PLGF、FIB、sICAM-1预测孕妇发生PA价值。结果:PA组PLGF(74.2±17.02pg/ml)、FIB(3.38±0.56g/L)低于非PA组(117.3±26.2pg/ml、4.37±0.83g/L),sICAM-1水平(967.18±242.14μg/L)高于非PA组(560.59±150.23μg/L),PA分级0级、Ⅰ级、Ⅱ~Ⅲ级孕妇PLGF、FIB、sICAM-1水平存在差异(均P<0.05)。Spearman分析显示,PLGF(r=-5.442)、FIB(r=-5.317)与PA严重程度呈负相关关系,sICAM-1(r=6.255)与PA严重程度呈正相关关系(均P<0.05)。ROC曲线分析,PLGF(AUC=0.830,95%CI0.753~0.906)、FIB(AUC=0.760,95%CI0.672~0.849)、sICAM-1(AUC=0.940,95%CI0.908~0.973)及联合检测(AUC=0.982,95%CI0.967~0.997)预测孕妇PA发生有一定价值,且联合预测价值提高。结论:孕晚期孕妇血PLGF、FIB、sICAM-1水平存在异常,且与PA病情程度具有相关性,3指标对预测孕妇发生PA有一定临床价值,且联合检测预测效能最高。Objective:To investigate the correlation between the levels of the soluble inter-cellular adhesion molecule-1(sICAM-1),fibrinogen(FIB)and placental growth factor(PLGF)of pregnant women during the third trimester of pregnancy and their placental abruption(PA).Methods:From January 2020 to March 2024,200 pregnant women suspected of PA were selected as the study objects.The postpartum diagnosis of PA was used as the gold standard,and these women were divided into study group(15o cases with PA)and control group(50 cases without PA).The levels of PLGF,FIB and sICAM-1 of the pregnant women in the two groups were detected.The levels of PLGF,FIB and sl-CAM-1 were compared among the pregnant women with the different disease grades of PA.Spearman analysis was used to explore the correlation between the levels of the PLGF,FIB and sICAM-1 of the women and the severity grading of their PA.The predictive values of the PLGF,FIB and sICAM-1 levels of the women for their PA occurrence were analyzed by receiver operator characteristic(ROC)curve.Results:The levels of PLGF(74.2±17.02 pg/ml)and FIB(3.38±0.56 g/L)of the women in the study group were significantly lower than those(117.3±26.2 pg/ml and 4.37±0.83 g/L)of the women in the control group,and the level of sICAM-1(967.18±242.14μg/L)of the women in the study group was significantly higher than that(560.59±150.23μg/L)of the women in the control group.There were significant differences in the PLGF,FIB and sICAM-1 levels among the women with PA grade O,I and II-II(all P<0.05).Spearman analysis showed that the PLGF level(r=-5.442)and the FIB level(r=-5.317)of the women were negatively correlated with the severity of their PA,and the sICAM-1 level(r=6.255)of the women was positively correlated with the severity of their PA(all P<0.05).ROC curve analysis showed that the PLGF level(AUC=0.830,95%CI 0.753-0.906),the FIB level(AUC=0.760,95%CI0.672-0.849),the sICAM-1 level(AUC-0.940,95%CI 0.672-0.849),95%CI 0.908-0.973)and the combined levels of the PLGF,FIB and sICAM-1(AUC 0.982,9

关 键 词：胎盘早剥 严重程度 胎盘生长因子 纤维蛋白原 可溶性细胞间黏附分子-1 相关性 预测 

分 类 号：R71[医药卫生—妇产科学]