孕妇血25-羟维生素D水平与炎性因子水平及不良妊娠结局关系  

Correlation between the 25-hydroxyvitamin D level of pregnant women and their inflammatory factor level and pregnancy outcomes

作　　者：陈云云 陶瑞雪 王丽娟 CHEN Yunyun;TAO Ruixue;WANG Lijuan(Hefei First People's Hospital,Hefei,Anhui Province,230001)

机构地区：[1]安徽省合肥市第一人民医院,230001

出　　处：《中国计划生育学杂志》2025年第1期195-198,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨孕妇25-羟维生素D(25-OH-D)水平与其炎症因子、妊娠期糖尿病(GDM)、子痫前期(PE)、孕期抑郁、不良妊娠结局的相关性。方法:选取2018年5月-2023年5月于本院产前检查孕妇120例,依据检测的25-OH-D水平分组,>30nmol/L为对照组(n=58),≤30nmol/L观察组(n=62),对比两组炎症因子水平、妊娠期糖尿病、子痫前期、孕期抑郁、不良妊娠结局发生情况;Spearman分析孕期25-OH-D水平与炎症因子、GDM、PE、孕期抑郁和不良妊娠结局的相关性。结果:研究期间对照组失访4例,纳入54例;观察组失访5例,纳入57例。观察组血清白介素-6(139.44±20.11pg/ml)、C反应蛋白(11.36±2.39mg/ml)水平高于对照组(89.62±11.36pg/ml、6.74±1.41mg/ml),降钙素原(44.03±3.59pg/ml)水平低于对照组(46.55±4.37pg/ml),GDM(50.9%)、PE(31.6%)、孕期抑郁发病率(35.1%)高于对照组(27.8%、13.0%、16.7%),不良妊娠结局总发生率(21.1%)高于对照组(5.6%)(均P<0.05);孕期25-OH-D水平与PCT呈正相关,与IL-6、CRP、GDM、PE、孕期抑郁和不良妊娠结局呈负相关(均P<0.05)。结论:孕期孕妇血清25-OH-D水平与炎症因子、GDM、PE、孕期抑郁、不良妊娠结局均具有相关性,临床需着重检测。Objective:To investigate the correlation between the 25-hydroxyvitamin D(25-OH-D)level of pregnant women and their inflammatory factor level,their occurrence of the gestational diabetes mellitus(GDM),preeclampsia(PE)and depression during pregnancy and their adverse pregnancy outcomes.Methods:A total of 120 pregnant women who underwent antenatal examination in the hospital from February 2018 to February 2023 were selected as research objects.These women were divided into control group(n=58)and observation group(n=62)according to their 25-OH-D level.The women with the 25-OH-D level>30nmol/L were included in the control group and the women with the 25-OH-D level≤30nmol/L were included in the observation group.The levels of the inflammatory factors and the incidences of GDM,PE,depression during pregnancy and adverse pregnancy outcomes of the women were compared between the two groups.Spearman analysis was used to explore the correlation between the 25-OH-D level of the women during pregnancy and their inflammatory factors level,and their incidences of GDM,PE,depression during pregnancy and adverse pregnancy outcomes.Results:The levels of the serum interleukin-6(139.44±20.11 pg/ml)and C-reactive protein(11.36±2.39 mg/ml)of the women in the observation group were significantly higher than those(89.62±11.36 pg/ml and 6.74±1.41 mg/ml)of the women in the control group.The level of procalcitonin(44.03±3.59 pg/ml)of the women in the observation group was significantly lower than that(46.55±4.37 pg/ml)of the women in the control group.The incidences of GDM(50.9%),PE(31.6%)and depression during pregnancy(35.1%)of the women in the observation group were significantly higher than those(27.8%,13.0%and 16.7%)of the women in the control group.The total incidence of adverse pregnancy outcomes(21.1%)of the women in the observation group was significantly higher than that(5.6%)of the women in the control group(P<0.05).The level of 25-OH-D of the women during pregnancy was positively correlated with their PCT level,and was neg

关 键 词：妊娠期 25-羟维生素D 炎症因子 妊娠期糖尿病 子痫前期 不良妊娠结局 相关性 

分 类 号：R714.2[医药卫生—妇产科学]