吸入给药治疗儿童呼吸系统疾病处方分析  

Prescription Analysis of Inhalation Administration for Children with Respiratory Diseases

作　　者：曹玉合 余进松 虎文涛 米洁[2] Cao Yuhe;Yu Jinsong;Hu Wentao;Mi Jie(Nanyang First People’s Hospital,Henan Nanyang 473000,China;Xi’an Children’s Hospital,Xi’an 710003,China)

机构地区：[1]南阳市第一人民医院,河南南阳473000 [2]西安市儿童医院,西安710003

出　　处：《儿科药学杂志》2025年第1期26-30,共5页Journal of Pediatric Pharmacy

基　　金：南阳市科技攻关计划项目,编号KJGG085。

摘　　要：目的:调查并评价吸入给药应用的合理性,为临床合理用药提供参考。方法:从西安市儿童医院2022年10-12月的门诊处方中,随机抽取用药途径为吸入给药处方1 000张。根据吸入装置的不同分为便携式吸入装置和雾化吸入装置。对处方中患儿年龄、临床诊断、药品名称、用法用量进行统计,对处方合理性进行点评分析。结果:1 000张处方中,便携式吸入装置处方286张,雾化吸入装置处方714张。吸入疗法主要应用于2~6岁患儿(48.1%),未见用于新生儿;单一使用吸入药的处方203张(20.3%),二联用药处方547张(54.7%),三联用药处方250张(25.0%),提示吸入用药联合用药率为79.7%。使用雾化吸入装置治疗的前3位疾病分别为支气管炎、肺炎和咽喉炎,使用频次最高的药物为吸入用布地奈德混悬剂。使用便携式吸入装置的前3位疾病分别为哮喘、上气道咳嗽综合征和喘息性支气管炎,使用频次最高的药物为丙酸氟替卡松吸入气雾剂。全院不合理处方占13.5%,主要包括遴选药物不适宜(3.2%)、给药剂量不适宜(2.5%)、装置选择不合理(1.5%)、给药途径不适宜(1.2%)等。结论:吸入给药广泛应用于治疗儿童呼吸系统疾病,联合用药普遍,存在一些不合理用药的情况,药师对临床医师做好吸入用药合理使用培训很有必要。Objective:To investigate and evaluate the rationality of inhalation administration,so as to provide reference for clinical rational drug use.Methods:Totally 1,000 prescriptions with inhalation administration were randomly extracted from the prescriptions in Xi'an Children's Hospital from Oct.to Dec.2022.The inhalation devices were divided into portable inhalation device and atomized inhalation device.The age of the children,clinical diagnosis,drug name,usage and dosage were statistically analyzed,and application rationality of the prescription was reviewed and analyzed.Results:Among the 1,000 prescriptions,286 prescriptions were for portable inhalation device and 714 prescriptions were for atomized inhalation device.Inhalation therapy was mainly used in children aged from 2 to 6 years(48.1%),yet not in neonates.There were 203 prescriptions(20.3%) for single use of inhaled drugs,547 prescriptions(54.7%) for double use of drugs,and 250 prescriptions(25.0%) for triple use of drugs,suggesting that the rate of drug combination of inhaled drugs was 79.7%.The top three diseases with atomized inhalation devices were bronchitis,pneumonia and pharyngitis,and the most frequently used drug was inhaled budesonide suspension.The top three diseases with portable inhalation devices were asthma,upper airway cough syndrome and asthmatic bronchitis,with inhaled aerosol of fluticasone propionate being the most frequently used drugs.Irrational prescriptions accounted for 13.5% in our hospital,mainly including inappropriate drug selection(3.2%),improper dosage(2.5%),irrational device selection(1.5%),and improper route of administration(1.2%).Conclusion:Inhalation administration is widely used in the treatment of pediatric respiratory diseases,and the combination of drugs is common,there are some irrational use of drugs,it is necessary for pharmacists to do a good job of training clinicians in the rational use of inhalation drugs.

关 键 词：儿童 雾化 呼吸系统疾病 吸入治疗 处方分析 

分 类 号：R969.3[医药卫生—药理学]