小剂量多巴胺辅助治疗新生儿坏死性小肠结肠炎的临床疗效及对炎症因子水平的影响  

Clinical Efficacy of Low-Dose Dopamine in the Adjuvant Treatment of Neonatal Necrotizing Enterocolitis and Effects on Levels of Inflammatory Factors

作　　者：张婕 苗耐英 李欢 刘新建 Zhang Jie;Miao Naiying;Li Huan;Liu Xinjian(Hebei China Petroleum Central Hospital,Hebei Langfang 065000,China)

机构地区：[1]河北中石油中心医院,河北廊坊065000

出　　处：《儿科药学杂志》2025年第1期41-44,共4页Journal of Pediatric Pharmacy

基　　金：廊坊市科技支撑计划项目,编号2023013037。

摘　　要：目的:探讨小剂量多巴胺对新生儿坏死性小肠结肠炎(NEC)的治疗效果。方法:选择我院收治的NEC新生儿70例,按随机数表法分为对照组和观察组各35例。对照组采用奥曲肽,观察组加用小剂量多巴胺[2.5μg/(kg·min)]。比较两组患儿总有效率、临床症状改善情况、炎症因子水平、不良反应发生情况。结果:观察组总有效率(94.29%)较对照组(77.14%)明显提高(P<0.01);观察组腹胀消退、腹泻缓解、大便改善时间显著短于对照组(P<0.01);观察组肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白细胞介素-8(IL-8)、IL-6水平显著低于对照组(P<0.01);两组患儿出现嗜睡、出汗等不良反应发生率比较差异无统计学意义(P>0.05)。结论:对NEC新生儿采用小剂量多巴胺治疗,可有效减轻机体炎症反应,促进患儿康复,具有较高的临床应用价值。Objective:To probe into the clinical efficacy of low-dose dopamine in the treatment of patients with neonatal necrotizing enterocolitis(NEC).Methods:Seventy neonates with NEC admitted into our hospital were randomly divided into the control group and observation group,with 35 cases in each group.The control group received octreotide,while the observation group was given low-dose dopamine of 2.5 μg/(kg·min).The total effective rate,improvement of clinical symptoms,inflammatory factors and adverse drug reactions were compared between two groups.Results:The total effective rate of observation group(94.29%) was significantly higher than that of the control group(77.14%,P<0.01).The time of abdominal distension,diarrhea relief and stool improvement in the observation group was significantly shorter than that in the control group(P<0.01).The levels of tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-8(IL-8) and IL-6 in observation group were significantly lower than those in control group(P<0.01).There was no significant difference in the incidence of sleepiness,sweating and other adverse drug reactions between two groups(P>0.05).Conclusion:Low-dose dopamine in the treatment of neonates with NEC can effectively reduce the inflammatory response and promote the recovery of the prognosis with higher clinical application value.

关 键 词：坏死性小肠结肠炎 新生儿 小剂量 多巴胺 炎症因子 

分 类 号：R722.1[医药卫生—儿科]