基于聚二甲基硅氧烷微流控芯片的微波生物传感器研究进展  

Research Progress of Microwave Biosensors Based on Polydimethylsiloxane Microfluidic Chips

作　　者：王彦雄 陈仟龙 周小满 梁峻阁 姜岩峰 强天 WANG Yan-Xiong;CHEN Qian-Long;ZHOU Xiao-Man;LIANG Jun-Ge;JIANG Yan-Feng;QIANG Tian(School of Integrated Circuits,Jiangnan University,Wuxi 214122,China;School of Biotechnology,Jiangnan University,Wuxi 214122,China)

机构地区：[1]江南大学集成电路学院,无锡214122 [2]江南大学生物工程学院,无锡214122

出　　处：《分析化学》2024年第12期1797-1806,共10页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金项目(No.61801146);中国博士后科学基金项目(No.2021M691284)资助。

摘　　要：微波生物传感器在食品安全检测、环境污染检测和生物医疗健康等领域应用广泛。与传统的光学和电化学传感器检测方案相比,微波传感具有精度高、穿透力强以及非接触检测等优点。聚二甲基硅氧烷(Polydimethylsiloxane,PDMS)在集成度、生物兼容性和加工性等方面具有诸多优良特性,微流控芯片具有耗材少、集成度高、样本量小、成本低廉和检测速度快等优点。集成PDMS微流控芯片的微波生物传感器可以结合上述两种技术的优势,提供快速、精准和低成本的检测方案,在生物医学领域具有重要的实际应用价值。本文首先介绍了微波生物传感器的基本特点和工作原理,总结了集成PDMS微流控芯片的多种微波生物传感器类型及其优缺点,以及近年来的研究进展,展望了新一代生物传感器芯片在一体化发展中存在的挑战及应对策略。Microwave biosensors are extensively applied in detection of food safety,environmental pollution and biomedical health.Compared to traditional optical and electrochemical sensing solutions,traditional optical and electrochemical sensor detection schemes,microwave sensing shows the advantages of high precision,strong penetration and non-contact detection.Polydimethylsiloxane(PDMS)exhibits numerous favorable characteristics in terms of integration,biocompatibility and processability.The integration of microwave biosensors with PDMS microfluidic chips allows for the full exploitation of the aforementioned advantages,thereby facilitating the provision of rapid,precise,and cost-effective detection solutions.These solutions are of considerable practical significance within the domain of biomedicine.This paper provides an overview of the fundamental characteristics and operational principles of microwave biosensors.It also offers a comprehensive account of the diverse types of microwave biosensors integrated with PDMS microfluidic chips,highlighting their respective advantages and disadvantages.Furthermore,it anticipates the challenges and potential solutions in the development of a novel generation of biosensor chip integration.This is with a view to providing a viable research and development concept for the advancement of medium and large-scale integrated-chip functional microfluidic chips in China.

关 键 词：微流控技术 微波技术 生物传感器 聚二甲基硅氧烷 芯片一体化 评述 

分 类 号：TP212.3[自动化与计算机技术—检测技术与自动化装置] TN492[自动化与计算机技术—控制科学与工程]