Co-profiling of translatome and transcriptome reveals the regulation of dynamic gene expression during Drosophila embryogenesis  

作　　者：Le Zhang Qiufang Liu Yulong Liu Bishan Ye Chuansheng Hu Xinhui Li Ling Bai Ming Cheng Mingzhu Zhao Hongmei Li Hua Li 

机构地区：[1]Jiangsu Province Engineering Research Center of Molecular Target Therapy and Companion Diagnostics in Oncology,Suzhou Vocational Health College,Suzhou 215009,China [2]Bio-ID Center,School of Biomedical Engineering,Shanghai Jiao Tong University,Shanghai 200240,China [3]Health School Attached to Shanghai University of Medicine&Health Sciences,Shanghai 200237,China [4]School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai 200240,China [5]Instrumental Analysis Center,Shanghai Jiao Tong University,Shanghai 200240,China [6]Department of Cardiology and Shanghai Institute of Precision Medicine,Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200125,China

出　　处：《Acta Biochimica et Biophysica Sinica》2024年第11期1711-1715,共5页生物化学与生物物理学报(英文版)

基　　金：This work was supported by the grants from the National Key R&D Program of China(No.2022YFF1202000,and Subproject No.2022YFF1202003);the Project of Jiangsu Province Engineering Research Center of Molecular Target Therapy and Companion Diagnostics in Oncology.

摘　　要：Eukaryotic gene expression is regulated at multiple levels,aiding in maintaining normal phenotypes and environmental adaptability.Transcriptional regulation complexity has been extensively studied using high-throughput sequencing,and previous studies have shown that different transcript isoforms can be produced through complex regulatory mechanisms via large-scale RNA sequencing.

关 键 词：DYNAMIC REGULATION ADAPTABILITY 

分 类 号：Q756[生物学—分子生物学]