Identification of the interaction between MAPK1 and Eimeria acervulina serine protease inhibitor: a preliminary functional study  

作　　者：Liyin Lian He Sun Jing Wang Wanjing Li Yifan Sheng Xinyue Gong Qian Sun Pu Wang Yadong Zheng Houhui Song 

机构地区：[1]College of Animal Science and Technology&College of Veterinary Medicine,Zhejiang A&F University,Key Laboratory of Applied Technology on Green Eco-Healthy Animal Husbandry of Zhejiang Province,Provincial Engineering Research Center for Animal Health Diagnostics&Advanced Technology,Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management,China Australia Joint Laboratory for Animal Health Big Data Analytics,Hangzhou 311300,China

出　　处：《Acta Biochimica et Biophysica Sinica》2024年第11期1716-1720,共5页生物化学与生物物理学报(英文版)

基　　金：This work was supported by the grants from the Zhejiang Provincial Natural Science Foundation of China(No.LY22C180001);the College Students’Innovation and Entrepreneurship Training Program(Nos.DKDY2022009,DKDY2022005,and DKDY2022002);the National Key Research and Development Program of China(No.2023YFD1801000).

摘　　要：Eimeria spp.can invade different intestines of chickens.Among them,Eimeria acervulina(E.acervulina,Ea)is the most virulent,and it is characterized by disruption of the intestinal nutrient uptake mechanism,leading to weight loss and even death.As a result,coccidia have caused a heavy burden on the poultry industry[1].Currently,understanding the invasion mechanism of E.acervulina in host cells is the basis for developing the most effective preventive method for coccidiosis.However,the specific mechanism of E.acervulina invasion is unclear,so the interactions between parasite and host cells need to be studied in depth.

关 键 词：INVASION PARASITE EIMERIA 

分 类 号：R382.2[医药卫生—医学寄生虫学]