胸腺五肽联合胰岛素辅助治疗肺结核合并2型糖尿病的临床效果  

Clinical effect of thymopentin combined with insulin in adjuvant treatment of pulmonary tuberculosis complicated with type 2 diabetes mellitus

作　　者：任万良[1] 来力伟 王科文 REN Wanliang;LAI Liwei;WANG Kewen(Baoji Center for Disease Control and Prevention,Baoji 721006;Baoji Third Hospital,Baoji 721000;the 987th Hospital of the Joint Logistic Support Force of the Chinese People's Liberation Army,Baoji 721006,China)

机构地区：[1]宝鸡市疾病预防控制中心,陕西宝鸡721006 [2]宝鸡第三医院,陕西宝鸡721000 [3]中国人民解放军联勤保障部队第九八七医院,陕西宝鸡721006

出　　处：《临床医学研究与实践》2025年第3期71-74,共4页Clinical Research and Practice

摘　　要：目的 探讨胸腺五肽联合胰岛素辅助治疗肺结核合并2型糖尿病的临床效果,为该病的治疗提供参考。方法 选择2017年3月至2021年11月住院治疗的60例肺结核合并2型糖尿病患者为研究对象,采用随机数字表法将其分为对照组和观察组,各30例。两组均接受常规治疗,对照组采用胰岛素治疗,观察组在对照组基础上加用胸腺五肽治疗。比较两组的临床疗效、血糖控制情况、免疫功能及不良反应发生情况。结果 观察组的治疗总有效率为100.00%,高于对照组的86.67%(P<0.05)。治疗后,两组的空腹血糖、餐后2 h血糖水平及糖化血红蛋白均低于治疗前(P<0.05);治疗后,两组的空腹血糖、餐后2 h血糖水平及糖化血红蛋白比较,差异无统计学意义(P>0.05)。治疗后,两组的CD3+、CD4+均高于治疗前,CD8+低于治疗前,且观察组优于对照组(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 胸腺五肽联合胰岛素辅助治疗肺结核合并2型糖尿病的效果显著,可提高血糖控制效果,改善免疫功能,且不会增加不良反应。Objective To explore the clinical effect of thymopentin combined with insulin in adjuvant treatment of pulmonary tuberculosis complicated with type 2 diabetes mellitus,and to provide reference for the treatment of the disease.Methods A total of 60 patients with pulmonary tuberculosis complicated with type 2 diabetes mellitus who were hospitalized from March 2017 to November 2021 were selected as the research objects.The patients were divided into control group and observation group by random number table method,with 30 cases in each group.Both groups received routine treatment,the control group was treated with insulin,and the observation group was treated with thymopentin on the basis of the control group.The clinical efficacy,blood glucose control,immune function and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 100.00%,which was higher than 86.67%in the control group(P<0.05).After treatment,the fasting blood glucose,2 h postprandial blood glucose levels and glycosylated hemoglobin of the two groups were lower than those before treatment(P<0.05);after treatment,there were no significant differences in fasting blood glucose,2 h postprandial blood glucose levels and glycosylated hemoglobin between the two groups(P>0.05).After treatment,the CD3+and CD4+in the two groups were higher than those before treatment,CD8+was lower than that before treatment,and those in the observation group were better than the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Thymopentin combined with insulin in adjuvant treatment of pulmonary tuberculosis complicated with type 2 diabetes mellitus has significant effect,which can elevate blood glucose control effect,and improve immune function without increasing adverse reactions.

关 键 词：胸腺五肽 胰岛素 肺结核 2型糖尿病 

分 类 号：R521[医药卫生—内科学]