富血小板血浆治疗膝骨性关节炎的细胞和分子机制研究进展  

Research progress on cellular and molecular mechanisms of platelet-rich plasma in the treatment of knee osteoarthritis

作　　者：林范璟 赖斌 许兆光 何发胜 徐乐勤[1] LIN Fanjing;LAI Bin;XU Zhaoguang;HE Fasheng;XU Leqin(Xiamen Hospital of TCM Affiliated to Fujian University of Traditional Chinese Medicine,Xiamen 361015,China)

机构地区：[1]福建中医药大学附属厦门中医院,福建厦门361015

出　　处：《临床医学研究与实践》2025年第3期187-190,共4页Clinical Research and Practice

基　　金：2022年厦门市医疗卫生指导性项目(No.3502Z20224ZD1161);2022年度厦门市自然科学基金项目-联合项目(No.3502Z20227367);福建省第四批老中医药专家学术经验继承项目(闽卫中医函[2022]544号);厦门市第六批中医后备人才培养项目(夏卫中医[2022]136号)。

摘　　要：膝骨性关节炎(KOA)是一种常见的慢性退行性关节疾病,主要临床表现为膝关节疼痛、畸形和功能障碍,严重影响患者的生活质量。富血小板血浆(PRP)是从自体外周血中分离获得的血小板浓缩物,含有多种生物活性因子,主要通过促进软骨细胞增殖、促进软骨基质形成、抑制炎症因子表达及促进骨髓间充质干细胞增殖与分化来发挥治疗KOA的作用。为提升临床医师对PRP关节腔注射治疗KOA的认识,本文从PRP的组成成分、制备方法、PRP关节腔注射治疗KOA的作用机制及临床研究四个方面综述了PRP关节腔注射治疗KOA的研究进展。Knee osteoarthritis(KOA)is a common chronic degenerative joint disease,the main clinical manifestations are knee pain,deformity and dysfunction,which seriously affect the quality of life of patients.Platelet rich plasma(PRP)is a platelet concentrate isolated from autologous peripheral blood,which contains a variety of bioactive factors,it plays a role in the treatment of KOA by promoting the proliferation of chondrocytes,promoting the formation of cartilage matrix,inhibiting the expression of inflammatory factors and promoting the proliferation and differentiation of bone marrow mesenchymal stem cells.In order to improve clinicians'understanding of PRP intra-articular injection in the treatment of KOA,this article reviews the research progress of PRP intra-articular injection in the treatment of KOA from four aspects:the composition and preparation method of PRP,the mechanism of PRP intra-articular injection in the treatment of KOA and clinical research.

关 键 词：富血小板血浆 膝骨性关节炎 生长因子 细胞因子 分子机制 

分 类 号：R684[医药卫生—骨科学]