抗真菌肽的结构优化与创新设计路径  

Structural Optimization and Innovative Design Methods of Antifungal Peptides

作　　者：冉启月 景梦芙 罗红丽[1] 廖国建[1] Ran Qi-yue;Jing Meng-fu;Luo Hong-li;Liao Guo-jian(College of Pharmaceutical Sciences,Southwest University,Chongqing 400715)

机构地区：[1]西南大学药学院,重庆400715

出　　处：《国外医药(抗生素分册)》2024年第6期373-381,共9页World Notes on Antibiotics

基　　金：2024年大学生创新创业训练计划项目(202410635075)。

摘　　要：数量种类有限的抗真菌抗生素过度使用促进病原菌产生耐药性,探索能够替代传统抗生素的新型疗法尤为关键。在这一背景下,抗真菌肽由于作用方式多样,较难使真菌形成耐药问题,在临床应用领域展现出极大的潜力。然而,天然抗真菌肽存在稳定性差、毒性高、研发周期长等缺陷,导致其设计和开发受到限制,因此抗真菌肽的设计与合成策略成为了近期研究热点。本文综合探讨了抗真菌肽的特点、来源、杀菌原理和研究现状,介绍了合理设计、组合化学和计算机辅助设计用于抗真菌肽开发的策略,旨在为抗真菌肽的进一步研究提供有价值的信息。The overuse of a limited range of antifungal antibiotics has led to the rise of drug-resistant pathogens,underscoring the urgent need for new therapeutic alternatives to traditional antibiotics.In this regard,antifungal peptides hold significant promise for clinical applications due to their diverse mechanisms of action and reduced likelihood of inducing drug resistance in fungi.However,issues with low stability,high toxicity,and protracted research and development cycles prevent natural antifungal peptides from being widely used in design.Consequently,the design and synthesis of antifungal peptides have become a focal point of recent research efforts.This article provides a comprehensive review of the characteristics,origins,and mechanisms of action of antimicrobial peptides,while also discussing current research developments.Additionally,it highlights various strategies for the development of antifungal peptides,including rational design,combinatorial chemistry,and computer-aided design,with the aim of offering valuable insights for advancing research in this field.

关 键 词：抗真菌肽 作用机制 结构改造 抗生素耐药性 肽设计 

分 类 号：R978.5[医药卫生—药品]