复方甘草酸苷联合谷胱甘肽对慢性乙型肝炎患者血清炎症因子及免疫功能的影响  

The Effect of Compound Glycyrrhetinic Acid Glycoside Combined with Glutathione on Serum Inflammatory Factors and Immune Function in Patients with Chronic Hepatitis B

作　　者：陈磊 司佳[1] CHEN Lei;SI Jia(Jiayuguan First People's Hospital,Jiayuguan 735100,China;不详)

机构地区：[1]嘉峪关市第一人民医院,甘肃嘉峪关735100

出　　处：《中外医学研究》2025年第3期11-14,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探析复方甘草酸苷联合谷胱甘肽对慢性乙型肝炎患者血清炎症因子及免疫功能的影响。方法:选取2021年1月—2023年1月嘉峪关市第一人民医院收治的120例慢性乙型肝炎患者作为研究对象,根据数字奇偶数法分为2组,其中对照组给予谷胱甘肽治疗,观察组在对照组基础上加用复方甘草酸苷,比较两组患者临床疗效、血清炎症因子[白细胞介素-4(IL-4)、血清P物质(SP)、肿瘤坏死因子-α(TNF-α)]、免疫功能(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)、)以及不良反应。结果:观察组总有效率高于对照组,差异有统计学意义(P<0.05);治疗12个月,两组IL-4、SP、TNF-α水平低于治疗前,且观察组较对照组更低,差异有统计学意义(P<0.05);治疗12个月,两组CD4^(+)、CD4^(+)/CD8^(+)水平高于治疗前,CD8^(+)低于治疗前,且观察组较对照组变化更明显,差异有统计学意义(P<0.05);两组不良反应发生情况比较,差异无统计学意义(P>0.05)。结论:复方甘草酸苷联合谷胱甘肽对慢性乙型肝炎患者疗效显著,可有效改善患者血清炎症因子,强化免疫功能。Objective:To explore the effects of compound glycyrrhetinic acid glycoside combined with glutathione on serum inflammatory factors and immune function in patients with chronic hepatitis B.Method:120 patients with chronic hepatitis B admitted to the hospital from February 2021 to February 2023 were selected as the study objects and divided into two groups based on odd and even numbers.The control group was treated with glutathione,while the observation group was treated with compound glycyrrhizin.The clinical efficacy,serum inflammatory factors[interleukin-4(IL-4),serum substance P(SP),tumor necrosis factor(TNF-α)],immune function(CD4^(+),CD8^(+),CD4^(+)/CD8^(+))and adverse reactions were compared between the two groups.Result:The total effective rate of the observation group was higher than that of the control group(P<0.05).Treatment for 12 months,the levels of IL-4,SP and TNF-αwere lower than those before treatment,and the observation group was even lower(P<0.05).After 12 months of treatment,the levels of CD4^(+)and CD4^(+)/CD8^(+)in both groups were higher than those before treatment,while CD8^(+)was lower than that before treatment,and the observation group showed more significant changes(P<0.05).There was no statistically significant difference in the comparison incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combination of compound glycyrrhizic acid glycoside and glutathione has a significant therapeutic effect on patients with chronic hepatitis B,effectively improving serum inflammatory factors,strengthening immune function.

关 键 词：复方甘草酸苷 谷胱甘肽 慢性乙型肝炎 炎症因子 免疫功能 

分 类 号：R512.62[医药卫生—内科学]