四红祛斑汤联合光子嫩肤技术对黄褐斑患者皮损的影响  

Effects of Sihong Quban decoction combined with photon skin rejuvenation technology on skin lesions in patients with chloasma

作　　者：王春梅[1] 郭敏[1] 曹译文[1] 王根林[1] WANG Chunmei;GUO Min;CAO Yiwen;WANG Genlin(Department of Dermatology,Taizhou Hospital of Traditional Chinese Medicine,Taizhou 225300,Jiangsu Province,China)

机构地区：[1]泰州市中医院皮肤科,江苏泰州225300

出　　处：《世界临床药物》2024年第12期1245-1251,共7页World Clinical Drug

摘　　要：目的探究四红祛斑汤联合光子嫩肤技术对黄褐斑患者皮损程度及皮脂含量的影响。方法选取2021年9月至2023年9月在本院确诊的黄褐斑患者100例,随机分为常规组和联合组,每组50例。常规组使用光子嫩肤技术治疗,联合组使用四红祛斑汤联合光子嫩肤技术治疗。观察两组患者治疗后的临床疗效、皮损程度、皮肤各项指标、血清氧化应激指标、性激素指标和不良反应发生状况。结果治疗后,联合组的总有效率为96.00%,常规组为76.00%,联合组显著高于常规组(P<0.05)。两组患者皮损颜色积分、皮损面积积分、皮损总积分、皮脂含量、色素斑、毛孔、皱纹、黄褐斑皮损面积与严重程度指数评分、丙二醛、促卵泡激素、黄体生成素及雌二醇水平均较治疗前显著降低,且联合组以上指标(除皮脂含量外)显著低于常规组(P<0.05),两组皮脂含量无显著差异(P>0.05)。两组患者皮肤含水量、皮肤弹性指数、超氧化物歧化酶(superoxide dismutase,SOD)和过氧化氢酶(catalase,CAT)水平较治疗前均显著提高(P<0.05),且联合组皮肤含水量、皮肤弹性指数、SOD和CAT水平显著高于常规组(P<0.05)。两组患者治疗期间不良反应发生率无显著差异(P>0.05)。结论四红祛斑汤联合光子嫩肤技术治疗黄褐斑能提高临床效果,减轻皮损程度和氧化应激反应,改善患者皮肤状态,调节人体血清性激素水平。Objective To explore the effects of Sihong Quban decoction combined with photon skin rejuvenation technology on the degree of skin lesions and sebum content in patients with chloasma.Methods One-hundred patients diagnosed with chloasma in our hospital from September 2021 to September 2023 were collected and randomly separated into conventional group and combination group,with 50 cases in each group.The conventional group was treated with photon skin rejuvenation technology,while the combination group was treated with Sihong Quban decoction combined with photon skin rejuvenation technology.The clinical efficacy,degree of skin lesions,skin indicators,oxidative stress indicators,serum sex hormone indicators,and adverse reactions were observed after treatment.Results After treatment,the total effective rate of the combination group was 96.00%,the conventional group was 76.00%,and the combination group was obviously higher than the conventional group(P<0.05).The skin color score,skin lesion area score,total skin lesion score,sebum content of skin lesions,pigmentation,pores,wrinkles,melasma area severity index score,malonaldehyde,follicle-stimulating hormone,luteinizing hormone,and estradiol levels of the two groups were obviously reduced compared to before treatment,and the above indicators(except for sebum content)in the combination group were obviously lower than those in the conventional group(P<0.05).There was no obvious difference in sebum content between the two groups(P>0.05).The skin moisture content,skin elasticity index,superoxide dismutase(SOD)and catalase(CAT)levels in both groups were obviously increased compared to before treatment(P<0.05),and the combination group had obviously higher skin moisture content,skin elasticity index,SOD and CAT levels than the conventional group(P<0.05).There was no significant difference in adverse reaction rate between the two groups during treatment(P>0.05).Conclusion Sihong Quban decoction combined with photon skin rejuvenation technology can improve clinical efficacy,re

关 键 词：四红祛斑汤 光子嫩肤技术 黄褐斑 皮损程度 皮脂含量 

分 类 号：R758.42[医药卫生—皮肤病学与性病学] R275.9[医药卫生—临床医学]