灯台叶颗粒联合甘氨酸茶碱钠治疗喘息性支气管炎的效果分析  

The analysis of therapeutic effect of Dengtaiye granules combined with glycine theophylline sodium in the treatment of asthmatic bronchitis

作　　者：于萍 张蓬华 柯洪琴 梁欢 梁文斌 喻志芳 YU Ping;ZHANG Penghua;KE Hongqin;LIANG Huan;LIANG Wenbin;YU Zhifang(Department of Pharmacy,Taihe Hospital,Hubei University of Medicine,Shiyan 442000,Hubei Province,China;Department of Respiratory and Critical Care Medicine,Taihe Hospital,Hubei University of Medicine,Shiyan 442000,Hubei Province,China)

机构地区：[1]十堰市太和医院(湖北医药学院附属医院)药学部,湖北十堰442000 [2]十堰市太和医院(湖北医药学院附属医院)呼吸与危重症医学科,湖北十堰442000

出　　处：《世界临床药物》2024年第12期1258-1262,共5页World Clinical Drug

基　　金：湖北省卫生健康委员会中医药科研项目(ZY2021M059)。

摘　　要：目的探讨灯台叶颗粒联合甘氨酸茶碱钠缓释片治疗慢性喘息性支气管炎急性发作的效果。方法选取十堰市太和医院2021年4月至2023年12月期间收治的慢性喘息性支气管炎急性发作患者106例,将其分为对照组及治疗组,每组53例。对照组采用甘氨酸茶碱钠缓释片治疗,治疗组采用灯台叶颗粒联合甘氨酸茶碱钠缓释片治疗。治疗7 d后判定两组患者的治疗效果,比较两组患者的中医症状改善时间、血清炎症指标和不良反应。结果治疗组的总有效率高于对照组(96.23%vs 84.91%,P<0.05)。治疗组咳嗽痰多、喘息、面赤心烦、大便干结的改善时间短于对照组(P<0.05)。治疗后,两组C反应蛋白、白介素(interleukin,IL)-6、IL-17及肿瘤坏死因子-α水平均降低(P<0.05),且治疗组低于对照组(P<0.05)。两组的不良反应发生率比较无显著差异(P>0.05)。结论灯台叶颗粒联合甘氨酸茶碱钠缓释片治疗慢性喘息性支气管炎急性发作可获得较理想效果,能快速改善患者的中医症状,有效降低体内炎症反应,且安全性较高。Objective To explore the therapeutic effect of Dengtaiye granules combined with glycine theophylline sodium sustained-release tablets in the treatment of acute exacerbation of chronic asthmatic bronchitis.Methods 106 patients with acute exacerbation of chronic asthmatic bronchitis admitted to Shiyan Taihe Hospital from April 2021 to December 2023 were selected and divided into the control group and the treatment group,and 53 cases in each group.The control group was treated with glycine theophylline sodium sustained-release tablets,and the treatment group was treated with Dengtaiye granules combined with glycine theophylline sodium sustained-release tablets.The therapeutic effects,the improvement time of traditional Chinese medicine symptoms,serum inflammation indicators,and adverse reactions between two groups were compared after 7 days of treatment.Results The total effective rate of the treatment group was higher than that of the control group(96.23%vs 84.91%,P<0.05).The improvement time of cough,phlegm accumulation,wheezing,facial redness and irritability,and dry stools in the treatment group was shorter than that in the control group(P<0.05).After treatment,C-reactive protein,interleukin(IL)-6,IL-17,and tumor necrosis factor-αwere decreased in the two groups(P<0.05),and the treatment group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Dengtaiye granules combined with glycine theophylline sodium sustained-release tablets can achieve ideal therapeutic effects in the treatment of acute exacerbation of chronic asthmatic bronchitis.It can quickly improve the traditional Chinese medicine symptoms of patients,effectively reduce the inflammatory response in the body,and has high safety.

关 键 词：灯台叶颗粒 甘氨酸茶碱钠缓释片 慢性喘息性支气管炎 急性发作 

分 类 号：R974.3[医药卫生—药品] R562.21[医药卫生—药学] R289