艾曲泊帕联合标准免疫抑制对再生障碍性贫血的临床疗效及对GATA-3、TGF-β及sFas的影响  

Clinical effect of eltrombopagcombined with standard immunosuppression in the treatment of aplastic anemia and its influence on GATA-3,TGF-βand sFas

作　　者：王聪 张玉霞 郭发慧 李倩 马文秀 韩雪萍 WANG Cong;ZHANG Yuxia;GUO Fahui;LI Qian;MA Wenxiu;HAN Xueping(Department of Hematology,Gansu Wuwei Tumour Hospital,Gansu Province Wuwei Academy of Medical Sciences,Wuwei 733000,Gansu Province,China;Laboratory of Hematology,Gansu Wuwei Tumour Hospital,Wuwei 733000,Gansu Province,China)

机构地区：[1]甘肃省武威肿瘤医院血液科,甘肃武威733000 [2]甘肃省武威肿瘤医院血液病实验室,甘肃武威733000

出　　处：《世界临床药物》2024年第12期1276-1280,共5页World Clinical Drug

摘　　要：目的探讨艾曲泊帕联合标准免疫抑制治疗再生障碍性贫血(aplastic anemia,AA)的临床效果及对GATA结合蛋白(GATA binding protein,GATA)-3、转化生长因子(transforming growth factor,TGF)-β及可溶性Fas分子(soluble Fas,sFas)水平的影响。方法选择2020年1月至2023年12月我院AA患者175例,将其分为观察组(n=88)和对照组(n=87)。对照组予标准免疫抑制治疗,观察组在对照组治疗基础上加用艾曲泊帕。比较两组疗效、GATA-3、TGF-β、sFas、血小板计数(platelet count,PLT)、白细胞(white blood cell,WBC)、免疫功能及不良反应发生情况。结果治疗后,观察组总有效率高于对照组(92.05%vs 81.61%,P<0.05)。两组血清GATA-3、TGF-β、sFas水平较前明显降低(P<0.05),且观察组低于对照组(P<0.05)。两组PLT、WBC水平较前明显升高(P<0.05),且观察组高于对照组(P<0.05)。两组白细胞分化抗原(cluster of differentiation,CD)4^(+)、CD4^(+)/CD8^(+)较前明显降低(P<0.05),且观察组低于对照组(P<0.05),CD8^(+)较前明显升高(P<0.05),且观察组高于对照组(P<0.05)。治疗期间,两组不良反应情况无显著差异(P>0.05)。结论在AA患者中予艾曲泊帕联合标准免疫抑制治疗效果较佳,可改善患者血清GATA-3、TGF-β及sFas水平。Objective To investigate the clinical effect of eltrombopag combined with standard immunosuppression in the treatment of aplastic anemia(AA)and its effect on GATA binding protein(GATA)-3,transforming growth factor(TGF)-βand soluble Fas(sFas)level.Methods A total of 175 patients with AA in our hospital from January 2020 to December 2023 were selected and divided into observation group(n=88)and control group(n=87).The control group was treated with standard immunosuppressive therapy,and the observation group was treated with eltrombopag on the basis of the control group.The clinical efficacy,GATA-3,TGF-β,sFas,platelet count(PLT),white blood cell(WBC),immune function and adverse reactions were compared between the two groups.Results After treatment,the total effective rate of observation group was higher than that of control group(92.05%vs 81.61%,P<0.05).Serum levels of GATA-3,TGF-βand sFas in both groups were significantly decreased(P<0.05),and the observation group was lower than the control group(P<0.05).The levels of PLT and WBC in both groups were significantly higher than before(P<0.05),and the observation group was higher than the control group(P<0.05).The cluster of differentiation(CD)4^(+)and CD4^(+)/CD8^(+)in both groups were significantly decreased than before(P<0.05),and the observation group was lower than the control group(P<0.05),while CD8^(+)was significantly increased than before(P<0.05),and the observation group was higher than the control group(P<0.05).During treatment,there was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion Eltrombopag combined with standard immunosuppressive therapy in AA is more effective,and can improve the serum levels of GATA-3,TGF-βand sFas.

关 键 词：艾曲泊帕 标准免疫抑制 再生障碍性贫血 GATA结合蛋白-3 转化生长因子-β 可溶性Fas分子 

分 类 号：R556.5[医药卫生—血液循环系统疾病]