机构地区:[1]苏州卫生职业技术学院,苏州215009 [2]苏州市药品检验检测研究中心,南京210000 [3]河北百草康神药业有限公司,苏州215104 [4]康美(亳州)华佗国际中药城商业有限公司,深州053000 [5]亳州市凯硕药业有限公司,亳州236800 [6]南京中医药大学附属医院,亳州236800
出 处:《药物分析杂志》2024年第12期2138-2147,共10页Chinese Journal of Pharmaceutical Analysis
基 金:苏州市基础研究计划(SKYD2023049,SKY2023042);江苏省高校“青蓝工程”青年骨干教师项目(2022-5-23)。
摘 要:目的:鉴别龙骨的真伪优劣,揭示龙骨色白者为佳的科学内涵。方法:以辨状论质为指导,利用性状、紫外荧光、电感耦合等离子体质谱、色彩分析仪、核辐检测仪,通过聚类分析、主成分分析、相关性分析对88批龙骨进行质量评价。结果:龙骨表面的龙骨斑为龙骨的关键鉴别点,龙骨斑主要由Mn元素构成,龙骨在365 nm荧光下新鲜断面可见亮蓝色荧光;在测定的42种元素中,龙骨伪品仅Mg、Zn元素含量高于正品,其他元素均低于正品,聚类分析显示所有的伪品单独聚为1类。龙骨可按颜色分为白色、青色、黄色、棕色4种类型,龙骨的颜色与元素存在相关性,a*越大,龙骨颜色越红,Fe及有害元素As、Cu、Pb、Cd含量越高。元素V与As、Cu、Pb、U均有强相关性,可作为重金属和有害元素的指标性元素。棕色龙骨放射性元素U及辐射值最高,黄色龙骨次之,青色龙骨低于黄色龙骨,白色龙骨最低。棕色龙骨中,放射性元素U及放射性辐射值最高,U含量平均值为0.021%,最高可达0.09%,平均辐射值为0.33μSv·h^(-1)(背景值为0.18μSv·h^(-1)),最高值为0.47μSv·h^(-1);黄色龙骨的U含量平均值为0.012%,最高为0.021%,平均辐射值为0.32μSv·h^(-1),最高值为0.39μSv·h^(-1);青色龙骨中,U含量平均值为0.0089%,最高为0.012%,平均辐射值为0.30μSv·h^(-1),最高值为0.35μSv·h^(-1);白色龙骨放射性元素U及放射性辐射值最低,U含量平均值为0.0067%,最高为0.0091%,辐射值最高为0.32μSv·h^(-1),平均辐射值为0.28μSv·h^(-1)。结论:从有害元素及放射安全性考虑,龙骨色白者品质较佳,棕色者品质较差。Objective:To identify the authenticity of the Longgu,and reveal the scientific illustration for superior quality of white Longgu.Methods:In this study,the quality of 88 batches of Longgu was evaluated by cluster analysis,principal component analysis and correlation analysis based on character,ultraviolet fluorescence and results obtained with inductively coupled plasma mass spectrometry,color analyzer and nuclear radiation detector.Results:The Longgu spots on the surface of Longgu were the key identification points of genuine Longgu,and the Longgu spots were mainly composed of Mn elements.Bright blue fluorescence could be seen in the fresh section of keel under 365 nm.Among the 42 elements determined,only Mg and Zn were higher in the fake Longgu than in the genuine Longgu.Other elements were lower in the fake Longgu than in the genuine Longgu.Heavy metals and harmful elements in counterfeit samples were below limits in pharmacopoeia,and cluster analysis showed that all counterfeit samples were grouped into one group separately.The Longgu could be divided into four color types:white,cyan,yellow and brown.The larger a*was,the redder the color of Longgu was,the higher the contents of Fe and harmful elements(As,Cu,Pb and Cd)were.And the contents of element V were strongly correlated with those of As,Cu,Pb and U,which could be used as index element of heavy metals and harmful elements.The contents of radioactive element U and the radiation values were highest in brown Longgu,second highest in yellow Longgu was the,lower in cyan Longgu,and lowest in white Longgu.The average content of U in brown Longgu was 0.021%with the highest content of 0.09%,and the average radiation value was 0.33μSv·h^(-1)(Background value was 0.18μSv·h^(-1))with the highest value of 0.47μSv·h^(-1).The average content of U in yellow Longgu was 0.012%with the highest content of 0.021%,and the average radiation value was 0.32μSv·h^(-1)with the highest value of 0.39μSv·h^(-1).The average content of U in cyan Longgu was 0.0089%with the high
关 键 词:龙骨 性状 荧光 电感耦合等离子质谱(ICP-MS) 元素 放射性 特性评价
分 类 号:R917[医药卫生—药物分析学]
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...