基于醛-胺席夫碱反应制备的葡聚糖水凝胶的结构和性能  

Structure and properties of dextran hydrogels prepared by aldehyde-amine Schiff base reaction

作　　者：李文鹏 蒋林芮 杨璟 陕绍云[1] 苏红莹[1] LI Wenpeng;JIANG Linrui;YANG Jing;SHAN Shaoyun;SU Hongying(Faculty of Chemical Engineering,Kunming University of Science and Technology,Kunming 650500,Yunnan,China)

机构地区：[1]昆明理工大学化学工程学院,云南昆明650500

出　　处：《精细化工》2025年第1期69-77,共9页Fine Chemicals

基　　金：国家自然科学基金项目(51963013);云南省“万人计划”青年拔尖人才专项项目(YNWR-QNBJ-2019-085)。

摘　　要：采用高碘酸钠对葡聚糖进行氧化,制备了氧化葡聚糖(Dex-CHO),Dex-CHO与胱胺二盐酸盐(CYS)发生醛-胺席夫碱交联反应制备了一系列葡聚糖水凝胶。采用1HNMR和FTIR对其进行了结构确认,通过SEM和荧光光谱考察了Dex-CHO中的醛基和CYS中的氨基的物质的量之比(简称醛氨比,下同)、葡聚糖重均相对分子质量(M_(w))、Dex-CHO质量浓度对葡聚糖水凝胶凝胶化时间、微观结构、溶胀性能及流变性能的影响。结果表明,葡聚糖水凝胶具有经典三维多孔结构和良好荧光性质,当葡聚糖Mw为40000、Dex-CHO质量浓度为0.0750 g/mL、醛氨比为1.49∶1时,制备的葡聚糖水凝胶具有更优良的三维网状结构(凝胶化时间2.5 min)、黏弹性能(弹性模量为165 kPa,黏性模量为12 kPa)及溶胀性能(30 min的溶胀率为5.9 g/g)。此外,酸敏感席夫碱键及还原敏感裂解二硫键使葡聚糖水凝胶的降解行为具有明显的pH和还原双敏感性。A series of dextran hydrogels were prepared from aldehyde-amine Schiff base cross-linking reaction between oxidized dextran(Dex-CHO),which was obtained by oxidization of dextran with sodium periodate,and cystamine dihydrochloride(CYS).The structure of the hydrogels was confirmed by 1HNMR and FTIR.The effects of molar ratio of aldehyde group in Dex-CHO and amino group in CYS(for short aldehyde-ammonia ratio,the same below),weight-average relative molecular mass(M_(w))of dextran and Dex-CHO mass concentration on the gelation time,microstructure,swelling properties and rheological properties of dextran hydrogel was analyzed by SEM and fluorescence spectroscopy.The results showed that dextran hydrogel had a classical three-dimensional porous structure and good fluorescence properties.When the dextran hydrogel,prepared from the reaction conditions of dextran Mw 40000,Dex-CHO mass concentration 0.0750 g/mL and aldehyde-ammonia ratio 1.49∶1,displayed better three-dimensional network structure(gelation time 2.5 min),viscoelastic properties(elastic modulus 165 kPa,viscosity modulus 12 kPa)and swelling properties(swelling rate 5.9 g/g at 30 min).In addition,acid-sensitive Schiff base bonds and reduction-sensitive cleavage disulfide bonds led to the obvious pH and reduction-dual sensitivity of dextran hydrogel degradation behavior.

关 键 词：葡聚糖 荧光水凝胶 醛-胺席夫碱反应 交联密度 环境敏感 功能材料 

分 类 号：TQ427.26[化学工程]