Uniform Granular Pigmentation as a Novel Dermoscopic Feature of Drug Reaction:A Cross-Sectional Study  

作　　者：Li-Xia Lu Shuang Zhao Ming-Liang Chen Xiang Chen Juan Su 

机构地区：[1]Department of Dermatology,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China [2]National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology,Changsha,Hunan 410008,China [3]Hunan Key Laboratory of Skin Cancer and Psoriasis,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China [4]Hunan Engineering Research Center of Skin Health and Disease,Changsha,Hunan 410008,China [5]National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Changsha,Hunan 410008,China

出　　处：《International Journal of Dermatology and Venereology》2024年第4期199-204,共6页国际皮肤性病学杂志(英文)

基　　金：funded by grants from the National Natural Science Foundation of China(Nos.82403284 and 8217114246);Hunan Provincial Natural Science Foundation(Nos.2023JJ40973 and 2023JJ40921).

摘　　要：Objective:In clinical practice,black-brown-gray pigment granules are common under dermoscopy.However,little is known about their clinical significance.We conducted this study to investigate the relationship between dermoscopy features and their representative pathological features.Methods:A cross-sectional study was conducted by searching clinical database in Xiangya Hospital,Central South University,from August 2017 to August 2022.Patients with full information on pigment granules and demographic and pathological findings were entered.Cases were reviewed for information regarding pathological and dermoscopic patterns.Fisher exact test was used to examine the correlation between individual histologic variables and established diagnoses.The depth of pigment granules showed a nonnormal distribution and was analyzed using a nonparametric test.Results:In total,data from 83 patients were included in this analysis.The presence of pigment granules under dermoscopy significantly indicated destruction of basal cells or pigment incontinence(91.5%,76/83).The pigment granules within lesions were divided into uniform and nonuniform patterns with respect to their size,color,and distribution.Uniform granular pigmentation was more likely to be associated with eosinophils(numerous or in aggregates,P<0.001)or perifollicular inflammatory infiltration in the dermis(P=0.008).Notably,brown pigment granules(P=0.024)and uniform granular pigmentation(P<0.001)were more likely to be induced by medications.Conclusion:Uniform granular pigmentation under dermoscopy is a novel indicator of a drug reaction and necessitates a detailed inquiry.

关 键 词：uniform granular pigmentation pigment granules drug reaction DERMOSCOPY 

分 类 号：R752.5[医药卫生—皮肤病学与性病学]