玉竹化学成分、药理作用研究进展及其质量标志物预测分析  

Research Progress on Chemical Composition and Pharmacological Effects of Polygonati Odorati Rhizoma and Prediction Analysis of Its Quality Markers

作　　者：王晨 于栋华[2] 阮佳鑫 王晓凡 刘苏杰 WANG Chen;YU Donghua;RUAN Jiaxin;WANG Xiaofan;LIU Sujie(Heilongjiang University of Traditional Chinese Medicine,Graduate School,Harbin 150040,China;Heilongjiang University of Traditional Chinese Medicine,Traditional Chinese Medicine Research Institute,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学研究生院,哈尔滨150040 [2]黑龙江中医药大学中医药研究院,哈尔滨150040

出　　处：《中国现代应用药学》2025年第1期158-172,共15页Chinese Journal of Modern Applied Pharmacy

摘　　要：玉竹为百合科植物玉竹Polygonatum odoratum(Mill.)Druce的干燥根茎,是中国传统中药材之一。研究表明,玉竹成分复杂,含有甾体皂苷类、多糖类、黄酮类、生物碱类、挥发油类等成分,具有降血糖、降血脂、抗疲劳、抗老化等活性。通过对玉竹的化学成分和药理作用进行综述,并基于质量标志物(quality marker,Q-Marker)理论,从植物亲缘性、特有性、有效性、可测性、复方配伍和网络药理学等方面预测玉竹的Q-Marker,初步预测3-O-β-D-吡喃葡萄糖基-(1-2)-[β-D-吡喃木糖基-(1-3)]-β-D-吡喃葡萄糖基-(1-4)-吡喃半乳糖基-25(S)-spirost-5(6)-en-3β,14alpho-diol_qt、4’,5,7-三羟基-6-甲基-8-甲氧基-羟基黄酮、4’,5,7-三羟基-6,8-二甲基-高异氟烷酮、多糖苷E_qt、4’,5,7-三羟基-6-甲基羟基黄酮、4’-甲氧基-5,7-二羟基-6,8-二甲基-高异氟烷酮、n-香豆酰酪胺、(Z)-3-(4-hydroxy-3-甲氧基-phenyl)-N-[2-(4-hydroxyphenyl)ethyl]acrylamide等可作为玉竹的主要Q-Marker,为玉竹的质量评价提供科学依据。通过抑制自由基的氧化而发挥抗疲劳作用的。Polygonati Odorati Rhizoma is the dried rhizome of Polygonatum odoratum(Mill.)Druce,a traditional Chinese medicinal materials.Studies have shown that the composition of Polygonati Odorati Rhizoma is complex,including steroidal saponins,polysaccharides,flavonoids,alkaloids,volatile oils and other components,with hypoglycemic,hypolipidemic,antifatigue,anti-aging and other activities.The chemical constituents and pharmacological effects of Polygonati Odorati Rhizoma were reviewed.Based on thetheory of quality marker(Q-Marker),the Q-Marker of Polygonati Odorati Rhizoma was predicted from the aspects of plant affinity and specificity,effectiveness.measurability,compound compatibility and network pharmacology.It was preliminarily predicted that 3-O-β-D-glucopyranosyl-(1-2)-[β-D-xylopyranosyl-(1-3)]-β-D-glucopyranosyl-(1-4)-galactopyranosyl-25(S)-spirost-5(6)-en-3β,14alpho-diol_qt,4’,5,7-trihydroxy-6-methyl-8-methoxy-hydroxyflavone,4’,5,7-trihydroxy-6,8-dimethylhomoisofluranone,polyglycoside E_qt,4’,5,7-trihydroxy-6-methyl-hydroxyflavone,4’-methoxy-5,7-dihydroxy-6,8-dimethylhomoisofluranone,n-coumaroyltyramine,(Z)-3-(4-hydroxy-3-methoxy-phenyl)-N-[2-(4-hydroxyphenyl)ethyl]acrylamide can be used as the main Q-Marker of Polygonati Odorati Rhizoma,which provides a scientific basis for the quality evaluation of Polygonati Odorati Rhizoma.

关 键 词：玉竹 质量标志物 高异黄酮 n-香豆酰酪胺 多糖 

分 类 号：R284[医药卫生—中药学] R285[医药卫生—中医学]