类风湿性关节炎与中医体质相关性研究的Meta分析  

Correlation Between Rheumatoid Arthritis and TCM Constitution:A Meta-analysis

作　　者：兰美岐 韩雨欣 胡晨静 陶庆文[2] 王建明[2] LAN Mei-qi;HAN Yu-xin;HU Chen-jing;TAO Qing-wen;WANG Jian-ming(Graduate School,Beijing University of Chinese Medicine,Beijing 100029;Traditional Chinese Medicine Department of Rheumatism China-Japan Friendship Hospital,Beijing 100029)

机构地区：[1]北京中医药大学研究生院,北京100029 [2]中日友好医院中医风湿病科,北京100029

出　　处：《世界中西医结合杂志》2025年第1期52-58,共7页World Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金面上项目(82274435);国家自然科学基金面上项目(82074223);第五批全国中医临床优秀人才研修项目(国中医药人教函[2022]178号)。

摘　　要：目的系统评价类风湿性关节炎(Rheumatoid arthritis,RA)患者中医体质分布规律。方法全面检索中国知网(CNKI)、万方数据库(Wanfang Data)、维普中文期刊数据库(VIP)、Web of Science、PubMed、Cochrane Library、Embase和CBM数据库建库至2023年11月30日期间所有涉及RA与中医体质相关性的研究,运用Sta⁃ta16.0软件进行单样本率的Meta分析。结果共纳入25项横断面研究和2项病例对照研究,共6481例样本。纳入的病例对照研究为高质量研究,横断面研究为中等质量研究。位于前三位的体质为阳虚质28.9%[95%CI(0.238,0.341)]、瘀血质16.8%[95%CI(0.119,0.218)]、阴虚质14.3%[95%CI(0.101,0.184)],其中阳虚质与RA联系最为紧密。男性患者痰湿质、湿热质更为常见,女性患者气虚质、瘀血质更为常见。阳虚质在55岁以上的患者更常见,瘀血质、阴虚质更常见于46~55岁之间的患者。华东、华南、西南、东北四个地区均是阳虚质最常见,西南地区平和质较为常见,东北地区痰湿质较为常见。结论阳虚质、瘀血质、阴虚质是RA患者的主要体质类型。未来需进一步探讨体质与RA的关系,为临床论治提供参考。Objective To systematically evaluate the distribution pattern of traditional Chinese medicine(TCM)constitution in patients with rheumatoid arthritis(RA).Methods A comprehensive search was conducted across CNKI,Wanfang Data,VIP,Web of Science,PubMed,Cochrane Library,Embase,and CBM databases,covering all studies on the correlation between RA and TCM constitution from database inception to November 30,2023.Meta-analysis of single-sample rates was performed using Stata 16.0 software.Results A total of 25 cross-sectional studies and 2 case-control studies were included,with a total of 6481 samples.The included case-control studies were of high quality,while the cross-sectional studies were of moderate quality.The three most common constitutions were yang deficiency constitution 28.9%[95%CI(0.238,0.341)],blood stasis constitution 16.8%[95%CI(0.119,0.218)],and yin deficiency con⁃stitution 14.3%[95%CI(0.101,0.184)],with yang deficiency being most strongly associated with RA.Phlegm-damp⁃ness and dampness-heat constitutions were more common in male patients,while qi deficiency and blood stasis constitu⁃tions were more common in female patients.Yang deficiency was more prevalent in patients aged 55 and above,while blood stasis and yin deficiency were more common in those aged 46~55.In terms of geographic distribution,yang deficiency was the most common constitution in East China,South China,Southwest China,and Northeast China,with the Southwest region also showing a higher prevalence of balanced constitution,and the Northeast region showing a higher prevalence of phlegm-dampness constitution.Conclusion Yang deficiency,blood stasis,and yin deficiency are the main body constitutions in RA patients.Further research is needed to explore the relationship between body constitution and RA,providing reference for clinical diagnosis and treatment.

关 键 词：类风湿性关节炎 中医体质 META分析 系统评价 分布规律 

分 类 号：R593.22[医药卫生—内科学]