基于“乙癸同源”理论探究滋肾育癸汤治疗卵巢早衰患者的疗效观察  

Clinical Efficacy of Zishen Yugui Decoction in the Treatment of Premature Ovarian Failure Based on the Theory of Yi(Liver)and Gui(Kidney)from Same Source

作　　者：池雷[1] 周云[1] CHI Lei;ZHOU Yun(Department of Gynecology,Jiangsu Province Hospital of Chinese Medicine,Nanjing Jiangsu 210029)

机构地区：[1]江苏省中医院妇科,江苏南京210029

出　　处：《世界中西医结合杂志》2025年第1期142-146,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：江苏省科技项目(BK20221423)。

摘　　要：目的观察基于“乙癸同源”理论用滋肾育癸汤治疗卵巢早衰(Premature ovarian failure,POF)的临床疗效。方法选取2021年12月—2023年12月期间江苏省中医院妇科收治的95例卵巢早衰患者,采用随机数字表法分为对照组47例和中西医组48例。对照组给予激素替代治疗,中西医组在对照组基础上给予滋肾育癸汤治疗,均治疗3个月。观察比较治疗前后两组患者中医证候评分、血清性激素[促卵泡生成素(Follicle-stimulating hormone,FSH)、黄体生成素(Luteinizing hormone,LH)、雌二醇(Estradiol,E2)]水平、窦卵泡数、卵巢体积变化,并评估临床疗效及安全性。结果治疗后中西医组临床总有效率93.75%(45/48)高于对照组78.72%(37/47),差异有统计学意义(P<0.05)。治疗后两组患者主症、次症及总分均较治疗前降低,差异有统计学意义(P<0.05);且中西医组主症、次症及总分均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者血清FSH、LH水平均较治疗前降低,E2水平均较治疗前升高,差异有统计学意义(P<0.05);且中西医组血清FSH、LH水平均明显低于对照组,E2水平明显高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者窦卵泡数及卵巢体积均较治疗前增加,差异有统计学意义(P<0.05);且中西医组窦卵泡数明显多于对照组,卵巢体积明显大于对照组,差异有统计学意义(P<0.05)。治疗期间,中西医组不良反应总发生率18.15%(9/48)与对照组12.77%(6/47)比较,差异无统计学意义(P>0.05)。结论滋肾育癸汤联合人工激素周期疗法治疗卵巢早衰,能有效缓解卵巢早衰患者症状,调节血清性激素水平,增加窦卵泡数和卵巢体积,且安全性高。Objective To observe the clinical efficacy of Zishen Yugui Decoction in the treatment of premature o⁃varian failure based on the theory of Yi(liver)and Gui(kidney)from same source.Methods Ninety-five patients with premature ovarian failure treated in the Department of Gynecology,Jiangsu Province Hospital of Chinese Medicine from De⁃cember 2021 to December 2023 were selected and assigned by the random number table method into a Chinese and West⁃ern medicine group(n=48)and a control group(n=47).The control group was treated with hormone replacement therapy(HRT),and the Chinese and Western medicine group was additionally treated with Zishen Yugui Decoction.The treatment in both groups lasted for 3 months.The TCM symptom scores,serum levels of sex hormones[follicle-stimulating hormone(FSH),luteinizing hormone(LH),and estradiol(E2)],sinus follicle number,and ovary volume were compared between the two groups as well as between before and after treatment.In addition,the clinical efficacy and safety were evaluated.Results After treatment,the total response rate in the Chinese and Western medicine group was 93.75%(45/48),which was higher than that(78.72%,37/47)in the control group(P<0.05).After treatment,the scores of primary and seconda⁃ry symptoms and the total TCM symptom score declined in both groups(P<0.05),and the TCM syndrome scores in the Chinese and Western medicine group were lower than those in the control group(P<0.05).After treatment,both groups showed lowered serum levels of FSH and LH and elevated E2 levels(P<0.05),and the Chinese and Western medicine group had lower FSH and LH levels and higher E2 level than the control group(P<0.05).After treatment,both groups showed increased sinus follicle number and ovarian volume(P<0.05),and the Chinese and western medicine group had higher sinus follicle number and larger ovarian volume than the control group(P<0.05).During the treatment period,the total incidence rates of adverse reactions in the Chinese and Western medicine group and the control group were

关 键 词：卵巢早衰 滋肾育癸汤 乙癸同源 

分 类 号：R711.75[医药卫生—妇产科学]