苍附导痰汤加减联合穴位贴敷治疗肥胖型青春期多囊卵巢综合征患者的疗效及对其体质量、代谢紊乱的影响  

Clinical Efficacy of Modified Cangfu Daotan Decoction Combined with Acupoint Ap⁃plication in Treatment of Obese Patients with Adolescent Polycystic Ovary Syndrome and Effect on Body Weight and Metabolic Disorders

作　　者：陈卉[1] 胡荣魁[1] 许家莹[1] CHEN Hui;HU Rong-kui;XU Jia-ying(Department of Gynecology,Jiangsu Province Hospital of Chinese Medicine,Nanjing Jiangsu 210029)

机构地区：[1]江苏省中医院妇科,江苏南京210029

出　　处：《世界中西医结合杂志》2025年第1期181-187,共7页World Journal of Integrated Traditional and Western Medicine

基　　金：江苏省中医药科技发展专项(2020ZX04);江苏省333工程项目(〔2022〕3-25-049);江苏省卫生健康发展研究中心开发课题(JSHD2022059);江苏省妇幼健康会委托研究课题(JSFY202205)。

摘　　要：目的探讨苍附导痰汤加减联合穴位贴敷治疗肥胖型青春期多囊卵巢综合征(Polycystic ovary syndrome,PCOS)的临床疗效及对其体质量、代谢紊乱的影响。方法选取2021年12月—2023年12月期间江苏省中医院收治的88例肥胖型青春期PCOS患者,按随机数字表法分为对照组和观察组,每组各44例。对照组接受常规生活方式指导及西药治疗,观察组在对照组基础上加用苍附导痰汤加减联合穴位贴敷治疗,均治疗3个周期。观察比较两组患者临床疗效、不良反应,治疗前后中医证候评分、体质量指数(Body mass index,BMI)、腰臀比(Waist to hip ratio,WHR)、性激素[睾酮(Testosterone,T)、促黄体生成素(Luteinizing hormone,LH)、促卵泡生成素(Follicle stimulating hormone,FSH)]水平及糖脂代谢指标[空腹血糖(Fasting blood glucose,FPG)、空腹胰岛素(Fasting insulin,FINS)、糖化血红蛋白(Glycosylated hemoglobin,HbA1c)、餐后2 h血糖(2 hour postprandial plasma glucose,2 h PG)、胰岛素抵抗指数(Homeostasis model assessment insulin resistance index,HOMA-IR)、总胆固醇(Total cholesterol,TC)、三酰甘油(Triglycerides,TG)、低密度脂蛋白胆固醇(Low-density lipoprotein cholesterol,LDL-C)与高密度脂蛋白胆固醇(High-density lipoprotein cholesterol,HDL-C)]变化。结果治疗后两组患者中医证候评分均较治疗前降低,差异有统计学意义(P<0.05);且观察组中医证候评分均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者BMI和WHR指标均较治疗前降低,差异有统计学意义(P<0.05);且观察组BMI和WHR指标均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者T、LH、LH/FSH指标均较治疗前降低,差异有统计学意义(P<0.05);且观察组T、LH、LH/FSH指标均明显低于对照组,差异有统计学意义(P<0.05)。两组患者治疗前后FSH比较,差异无统计学意义(P>0.05)。治疗后两组患者FINS、HbA1c、HOMA-IR、FPG、2 h PG指标均较治�Objective To explore the clinical efficacy of Cangfu Daotan Decoction combined with acupoint application in the treatment of obese adolescent polycystic ovary syndrome(PCOS),and its effect on body weight and metabolic disor⁃ders.Methods A total of 88 obese adolescent PCOS patients treated at Jiangsu Province Hospital of Chinese Medicine from December 2021 to December 2023 were selected and randomly divided into a control group and an observation group according to a random number table,with 44 patients in each group.The control group received conventional lifestyle guid⁃ance and Western medicine treatment,while the observation group received Cangfu Daotan Decoction combined with acu⁃point application on the basis of the control group treatment.Both groups were treated for three cycles.Clinical efficacy,ad⁃verse reactions,traditional Chinese medicine(TCM)syndrome scores,body mass index(BMI),waist-to-hip ratio(WHR),sex hormones[testosterone(T),luteinizing hormone(LH),follicle-stimulating hormone(FSH),and glucose and lipid metabolism indicators(fasting blood glucose(FPG),fasting insulin(FINS),homeostasis model assessment insulin resistance index(HOMA-IR),total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),and high-density lipoprotein cholesterol(HDL-C)]in both groups were compared before and after treatment.Results After treatment,both groups showed significant reductions in TCM syndrome scores compared to those before treatment(P<0.05).The observation group showed significantly lower TCM syndrome scores than the control group(P<0.05).After treatment,both groups showed reductions in BMI and WHR compared to those before treatment(P<0.05).The observa⁃tion group had significantly lower BMI and WHR than the control group(P<0.05).After treatment,T,LH,and LH/FSH in both groups were lower than those before treatment(P<0.05).After treatment,the observation group showed significant⁃ly lower levels of T,LH,and LH/FSH than the control group(P<0.05).There was no significant difference

关 键 词：多囊卵巢综合征 肥胖 青春期 苍附导痰汤 穴位贴敷 体质量 代谢紊乱 

分 类 号：R711.75[医药卫生—妇产科学]